Porogen compositions, methods of making and uses

Abstract

The present specification discloses porogen compositions comprising a core material and shell material, methods of making such porogen compositions, methods of forming such porous materials using such porogen compositions, biocompatible implantable devices comprising such porous materials, and methods of making such biocompatible implantable devices.

1 . A porogen composition useful for making a porous material and/or a textured surface, the porogen composition comprising:
 a) a shell material; and   b) a core material;   wherein the shell material has a melting temperature that is lower than a melting temperature of the core material.   
     
     
         2 . The porogen composition of  claim 1 , wherein the shell material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a surfactant and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof. 
     
     
         3 . The porogen composition of  claim 1 , wherein the core material is a salt and its derivatives, a ceramic and/or its derivatives, a sugar and its derivatives, a polysaccharide and its derivatives, a wax and its derivatives, a metal and its derivatives, a water soluble solid and its derivatives, a polymer and its derivatives, composites thereof, or combinations thereof. 
     
     
         4 . The porogen composition of  claim 1 , wherein the core material is a sugar. 
     
     
         5 . The porogen composition of  claim 1 , wherein the shell material is a polymer. 
     
     
         6 . The porogen composition of  claim 1 , wherein the core material is a sugar and the shell material is a polymer. 
     
     
         7 . The porogen composition of  claim 1  wherein the core material comprises sucrose. 
     
     
         8 . The porogen composition of  claim 1  wherein the core material comprises a starch. 
     
     
         9 . The porogen composition of  claim 1  wherein the shell material is polyethylene glycol. 
     
     
         10 . The porogen composition of  claim 9  wherein the core material is a sugar. 
     
     
         11 . A porogen composition useful for making a porous material and/or a textured surface, the porogen composition comprising:
 a) a shell material; and   b) a core material;   wherein under a given physical or physicochemical treatment the shell material is fusible and the core material is non-fusible.   
     
     
         12 . The porogen composition of  claim 11 , wherein the shell fusion occurs by a physical state change from solid phase to liquid or rubbery phase. 
     
     
         13 . The porogen composition of  claim 11 , wherein the physicochemical treatment is heat or an organic solvent. 
     
     
         14 . The porogen composition of  claim 11 , wherein the core material is a sugar. 
     
     
         15 . The porogen composition of  claim 11 , wherein the shell material is a polymer. 
     
     
         16 . The porogen composition of  claim 11 , wherein the core material is a sugar and the shell material is a polymer. 
     
     
         17 . The porogen composition of  claim 11 , wherein the core material comprises sucrose. 
     
     
         18 . The porogen composition of  claim 11 , wherein the core material comprises a starch. 
     
     
         19 . The porogen composition of  claim 11 , wherein the shell material is polyethylene glycol. 
     
     
         20 . The porogen composition of  claim 19  wherein the core material is a sugar.