Methods of therapeutic treatment of eyes and other human tissues using an oxygen-enriched solution

Abstract

Particular embodiments disclosed herein relate to electrokinetically altered gas-enriched fluids, methods of making the same, systems for making the same and/or methods of treatment utilizing the gas-enriched fluids for eye related conditions and/or diseases. In certain embodiments, the electrokinetically altered gas-enriched fluid is oxygen-enriched water. Certain embodiments relate to cosmetic and/or therapeutic fluids and/or methods of treatment utilizing the fluids to treat a cosmetic and/or therapeutic symptom related to eye conditions and/or diseases.

1 . A method of treating an eye condition of a subject, comprising contacting the eye of a subject in need thereof with an effective amount of an electrokinetically altered oxygenated aqueous fluid comprising an ionic aqueous solution of charge-stabilized oxygen-containing nanostructures having an average diameter of less than 100 nanometers and stably configured in the ionic aqueous fluid an amount sufficient to promote treating an eye condition upon contacting the eye of a subject by the fluid. 
     
     
         2 . The method according to  claim 1 , wherein the gas-enriched fluid comprises a saline solution. 
     
     
         3 . The method according to  claim 1 , wherein the gas-enriched fluid comprises a contact lens solution. 
     
     
         4 . The method according to  claim 3 , wherein the contact lens solution comprises a multi-use contact lens solution. 
     
     
         5 . The method according to  claim 3 , wherein the contact lens solution comprises a storage solution. 
     
     
         6 . The method according to  claim 3 , wherein the contact lens solution comprises a wetting solution. 
     
     
         7 . The method according to  claim 3 , wherein the contact lens solution comprises a cleaning solution. 
     
     
         8 . The method according to  claim 1 , wherein the gas-enriched fluid inhibits the growth of  Pseudomonas  bacteria. 
     
     
         9 . The method according to  claim 1 , wherein the condition is selected from the group consisting of dry eye, corneal irritation, bacterial infection, allergy irritation, and cellular damage. 
     
     
         10 . The method according to  claim 9  wherein the cellular damage is the result of a wound. 
     
     
         11 . The method according to  claim 10  wherein the wound is selected from the group consisting of: lacerations, abrasions, rupture, puncture wounds, chemical, thermal, or radiation-induced burns, cuts, scrapes, incisions, blisters, ulcers, and surgical wounds. 
     
     
         12 . The method according to  claim 11  wherein the surgical wound is a result of a surgery selected from the group consisting of: laser keratotomy, cataract removal, lens implantation or removal, corneal alterations, laser-assisted in situ keratomileusis (LASIK), intraLASIK, extracapsular surgery, phacoemulsification, vitreoretinal surgery, glaucoma procedures, neuro-ophthalmic surgery, strabismus surgery, and any combination thereof. 
     
     
         13 . The method according to  claim 1  wherein the gas-enriched fluid further comprises a therapeutic agent selected from the group consisting of: anti-microbial agent, anti-inflammatory agent, pain reliever, anesthetic, vitamin, cytokine, adjuvant, preservative, salt, and any combination thereof. 
     
     
         14 . A method of forming a contact lens comprising forming a lens from a polymeric compound and a gas-enriched fluid. 
     
     
         15 . The method of  claim 14  wherein the step of forming the contact lens is performed by a spin-casting process. 
     
     
         16 . The method of  claim 14  wherein the step of forming the contact lens is performed by a cast molding process. 
     
     
         17 . The method of  claim 14  wherein the step of forming the contact lens is performed by a lathe cutting process. 
     
     
         18 . A gas-enriched fluid composition for eye treatment, comprising a gas-enriched fluid, wherein the fluid inhibits the growth of  Pseudomonas.    
     
     
         19 . The fluid of  claim 18 , comprising solvated electrons.