Methods for treatment of thiol-containing compound deficient conditions

Abstract

Methods for therapy of cystic fibrosis and other conditions are provided. The methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e. ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments include the use of agents to modulate transport of thiol-containing compounds within the cell. Therapeutic methods involve the administration of such agents to a patient afflicted with cystic fibrosis and/or another condition responsive to stimulation of thiol-containing compound transport.

1 - 54 . (canceled) 
     
     
         55 . A method for treating inflammatory lung disease, comprising administering an agent to a subject having inflammatory lung disease wherein the agent is capable of increasing transport from a cell of a compound containing thiol-groups, wherein the agent is selected from sulfasalazine, p-amino salicyclic acid and 5-sulfosalicylic acid and treating the inflammatory lung disease in the subject. 
     
     
         56 . The method of  claim 55 , wherein the inflammatory lung disease is an interstitial lung disease. 
     
     
         57 . The method of  claim 55 , wherein the inflammatory lung disease is cystic fibrosis. 
     
     
         58 . The method of  claim 55 , wherein the transporter system comprises at least one transporter selected from the group consisting of an MRP-2 (multi-drug resistance-associated protein) transporter, an MRP-1 (multi-drug resistance-associated protein) transporter; an MDR-1 (multi-drug resistance) transporter and cystic fibrosis transmembrane conductance regulator (CFTR). 
     
     
         59 . The method of  claim 55 , wherein the composition further comprises a delivery vehicle.