Enhanced Delivery of Nicotine, THC, Tobacco, Cannabidiol or Base Alkaloid from an Electronic Cigarette or Other Vapor or Smoke Producing Device Through Use of an Absorption Conditioning Unit

Abstract

A method for the administration of nicotine, THC, tobacco, cannabidiol or a base alkaloid includes administering in the oral or nasal cavity an absorption conditioning unit having at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, to the mammal, and then administering by inhalation a bioactive agent selected from the group consisting of nicotine, THC, cannabidiol and a base alkaloid. The absorption conditioning unit may be in a dosage form not containing a drug. The absorption conditioning unit may create a pH in the oral cavity or nasal cavity of 7.8-10 for a period of ten minutes or more after administration, the dosage form not containing an acid and not containing a drug.

We claim: 
     
         1 . A method for the administration of nicotine, THC, cannabidiol or a base alkaloid to a mammal, comprising:
 administering an absorption conditioning unit in the oral or nasal cavity, comprising at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, to the mammal; and   administering by inhalation a bioactive agent selected from the group consisting of nicotine, THC, tobacco, cannabidiol and a base alkaloid.   
     
     
         2 . The method according to  claim 1 , wherein the absorption conditioning unit does not contain a bioactive. 
     
     
         3 . The method according to  claim 1 , wherein the absorption conditioning unit does not contain a drug. 
     
     
         4 . The method according to  claim 3 , wherein the absorption conditioning unit does not contain an acid. 
     
     
         5 . The method according to  claim 1 , wherein the absorption conditioning unit does not contain an acid. 
     
     
         6 . The method according to  claim 1 , wherein the absorption conditioning unit includes at least the buffer agent. 
     
     
         7 . The method according to  claim 1 , wherein the absorption conditioning unit includes at least the capturing agent, and the capturing agent has mucoadhesive properties. 
     
     
         8 . The method according to  claim 1 , wherein the bioactive agent is a base alkaloid comprising cocaine. 
     
     
         9 . A method for the administration of nicotine, THC, cannabidiol, cocaine or abase alkaloid to a mammal, comprising:
 administering an absorption conditioning unit including at least at least one material that creates a pH in the oral cavity of 7.8-10 for a period of ten minutes or more after administration; and   administering by inhalation a bioactive agent selected from the group consisting of nicotine, THC, tobacco, cannabidiol and a base alkaloid.   
     
     
         10 . The method according to  claim 9 , wherein the absorption conditioning unit does not contain a bioactive. 
     
     
         11 . The method according to  claim 9 , wherein the absorption conditioning unit does not contain an acid. 
     
     
         12 . The method according to  claim 9 , wherein the absorption conditioning unit does not contain a drug. 
     
     
         13 . The method according to  claim 9 , wherein the absorption conditioning unit includes at least a buffer agent. 
     
     
         14 . The method according to  claim 9 , wherein the absorption conditioning unit includes at least a capturing agent having mucoadhesive properties. 
     
     
         15 . The method according to  claim 9 , wherein the bioactive agent is a base alkaloid comprising cocaine. 
     
     
         16 . An absorption conditioning unit, comprising a dosage form including at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, wherein said absorption conditioning unit (i) does not have an essentially acidic character, (ii) does not contain a drug, (iii) does not contain THC or other Marijuana derived active ingredient, and (iv) does not contain tobacco except for trace amounts in flavor. 
     
     
         17 . The absorption conditioning unit according to  claim 16 , wherein the absorption conditioning unit does not contain an acid. 
     
     
         18 . The absorption conditioning unit according to  claim 16 , wherein the absorption conditioning unit includes at least the buffer agent. 
     
     
         19 . The absorption conditioning unit according to  claim 18 , wherein the buffer agent is configured to create a pH in the oral cavity of 7.8-10 for a period of ten minutes or more after administration 
     
     
         20 . The absorption conditioning unit according to  claim 16 , wherein the absorption conditioning unit includes at least the capturing agent, and the capturing agent has mucoadhesive properties. 
     
     
         21 . An absorption conditioning unit, comprising a dosage form including at least at least one material that creates a pH in the oral cavity of 7.8-10 for a period of ten minutes or more after administration, the dosage form not containing an acid and not containing a drug. 
     
     
         22 . The absorption conditioning unit according to  claim 21 , wherein the absorption conditioning unit includes at least a capturing agent. 
     
     
         23 . The absorption conditioning unit according to  claim 22 , wherein the capturing agent has mucoadhesive properties. 
     
     
         24 . A method for the administration of nicotine, THC, cannabidiol, or base alkaloid to a mammal, comprising:
 administering an absorption conditioning unit in the nasal cavity, comprising at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, to the mammal; and   separately administering a bioactive agent in the nasal cavity selected from the group consisting of nicotine, THC, tobacco, cannabidiol, and a base alkaloid.   
     
     
         25 . The method according to  claim 24 , wherein the bioactive agent is a base alkaloid comprising cocaine. 
     
     
         26 . A method for the administration of nicotine, THC, cannabidiol or a base alkaloid to a mammal, comprising:
 administering an absorption conditioning unit in the oral cavity, comprising at least two agents selected from the group consisting of (a) a buffer agent, (b) a capturing agent, (c) a penetration agent, and (d) a thermal agent, to the mammal; and   separately administering a bioactive agent selected from the group consisting of nicotine, THC, tobacco, cannabidiol and a base alkaloid, where such bioactive agent is contained in a solid, semi-solid or liquid based dosage form.   
     
     
         27 . The method according to  claim 26 , wherein the bioactive agent is a base alkaloid comprising cocaine.