Novel pharmaceutical formulation of cefixime for enhanced bioavailability

Abstract

A chewable tablet comprising Cefixime having a mean particle size between 20μ and 120μ wherein the said composition demonstrates bioequivalence to a suspension of Cefixime trihydrate. The process of preparation of the chewable tablet comprises the steps of optionally micronizing Cefixime such that the mean particle size of the Cefixime particles is between 20μ and 120μ, blending with other excipients, roll compaction, milling to form granules, blending to form a secondary blend and compression of the secondary blend to form tablets.

1 . A process of preparing a chewable tablet comprising Cefixime, the process comprising: optionally, micronizing Cefixime to obtain Cefixime particles of mean particle size 20μ to 120μ; blending cefixime, mannitol, hydroxypropyl cellulose and crospovidone; subjecting the blend to slugging; milling the slugs to obtain granules; blending the granules with one or more pharmaceutically acceptable excipients to obtain a secondary blend; and compressing the secondary blend to obtain a chewable tablet. 
     
     
         2 . The process of  claim 1 , wherein the pharmaceutically acceptable excipient is selected from the group consisting of one or more fruit flavoring agents, lubricants, sweetening agents, and coloring agents. 
     
     
         3 . The process of  claim 2 , wherein the fruit flavoring agent is selected from the group consisting of strawberry flavour, tutti frutti flavour, flavour fantasy permaseal and combinations thereof. 
     
     
         4 . The process of  claim 2 , wherein the lubricant is selected from the group consisting of colloidal silicon dioxide and magnesium stearate. 
     
     
         5 . The chewable tablet comprising cefixime prepared by the process of  claim 1 .