US2014171407A1PendingUtilityA1
1,7-diazacarbazoles and methods of use
Est. expiryDec 16, 2029(~3.4 yrs left)· nominal 20-yr term from priority
Inventors:Hazel Joan DykeLewis GazzardKaren WilliamsHuifen ChenSamuel KintzJoy DrobnickJoseph P. LyssikatosSimon Charles GoodacreCalum MacleodCharles Ellwood
A61K 31/4375A61K 45/06A61K 31/4545A61P 43/00A61K 31/5377A61P 35/02C07D 471/14C07D 519/00A61K 31/55A61K 31/496C07D 453/02A61K 31/439A61P 35/00A61K 31/437C07D 413/12
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Claims
Abstract
The invention relates to 1,7-diazacarbazole compounds of Formula (I), (I-a) and (I-b) which are useful as kinase inhibitors, more specifically useful as checkpoint kinase 1 (chk1) inhibitors, thus useful as cancer therapeutics. The invention also relates to compositions, more specifically pharmaceutical compositions comprising these compounds and methods of using the same to treat various forms of cancer and hyperproliferative disorders, as well as methods of using the compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
Claims
exact text as granted — not AI-modifiedWe claim:
1 . A compound of formula (I), (I-a), or (I-b), or a solvate, hydrate or salt thereof:
X is CR 2 or N;
Y is CR 4 or N;
Z is CR 8 or N; provided that no more than one of X, Y and Z is N at the same time;
R 2 is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , C 1 -C 5 alkyl, —O(C 1 -C 5 alkyl), —S(C 1 -C 5 alkyl), or N(R 22 ) 2 ;
R 3 is H, halo, CN, —O—R 9 , —N(R 22 )—R 9 , —S(O) p —R 9 , or R 9 ;
p is 0, 1 or 2;
R 4 is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , —(CR 14 R 15 ) n C(═Y′)OR 11 , —(CR 14 R 15 ) n C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 11 R 12 , —(CR 14 R 15 ) n OR 11 , —(CR 14 R 15 ) n S(O) p R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)OR 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 SO 2 R 11 , —(CR 14 R 15 ) n OC(═Y′)R 11 , —(CR 14 R 15 ) n OC(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13 groups;
each n is independently 0-5;
R 5 is H, halo, CN, CF 3 , —OCF 3 , OH, —NO 2 , —(CR 14 R 15 ) n C(═Y′)OR 11 , —(CR 14 R 15 ) n C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 C(═Y′)R 11 , —(CR 14 R 15 ) n NR 11 R 12 , —(CR 14 R 15 ) n OR 11 , —(CR 14 R 15 ) n S(O) p R 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)OR 11 , —(CR 14 R 15 ) n NR 12 C(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n NR 12 SO 2 R 11 , —(CR 14 R 15 ) n OC(═Y′)R 11 , —(CR 14 R 15 ) n OC(═Y′)NR 11 R 12 , —(CR 14 R 15 ) n S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl wherein the said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13 groups;
R 6 is H, CN, —CF 3 , —OCF 3 , halo, —C(═Y′)OR 11 , —C(═Y′)NR 11 R 12 , —OR 11 , —OC(═Y′)R 11 , —NR 11 R 12 , —NR 12 C(═Y′)R 11 , —NR 12 C(═Y′)NR 11 R 12 , —NR 12 S(O) q R 11 , —SR 11 , —S(O)R 11 , —S(O) 2 R 11 , —OC(═Y′)NR 11 R 12 , —S(O) 2 NR 11 R 12 , alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl wherein said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one to four R 13 groups;
R 7 is H, OH, CN, O(C 1 -C 3 alkyl), or C 1 -C 4 alkyl, wherein each said alkyl is optionally substituted with one to three groups independently selected from halo, N(R 22 ) 2 or OR 22 ;
R 8 is H, halo, CN, NO 2 , N(R 22 ) 2 , OH, O(C 1 -C 3 alkyl), or C 1 -C 3 alkyl, wherein each said alkyl is optionally substituted with one to three fluoro groups;
each R 9 is independently alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, wherein each member of R 9 is independently substituted with one to three R 10 groups;
each R 10 is independently H, CN, —CF 3 , —OCF 3 , —NO 2 , halo, R 11 , —OR 11 , —NR 12 C(═Y′)R 11 , —NR 12 C(═NR 12 )R 11 , —NR 12 S(O) q R 11 , —SR 11 , —NR 11 R 12 , oxo, —C(═Y′)OR 11 , —C(═Y′)NR 11 R 12 , —S(O) q R 11 , —NR 12 C(═Y′)OR 11 , —NR 12 C(═Y′)NR 11 R 12 , —OC(═Y′)R 11 , —OC(═Y′)NR 11 R 12 , or —S(O) 2 NR 11 R 12 ;
each q independently is 1 or 2;
R 11 and R 12 are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 13 groups, wherein two geminal R 13 groups are optionally taken together with the atom to which they are attached to form a 3-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 18 groups;
R 11 and R 12 are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13 groups;
each R 13 is independently halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —(CR 14 R 15 ) n C(═Y′)R 16 , —(CR 14 R 15 ) n C(═Y′)OR 16 , —(CR 14 R 15 ) n C(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n NR 16 R 17 , —(CR 14 R 15 ) n OR 16 , —(CR 14 R 15 ) n SR 16 , —(CR 14 R 15 ) n NR 16 C(═Y′)R 17 , —(CR 14 R 15 ) n NR 16 C(═Y′)OR 17 , —(CR 14 R 15 ) n NR 17 C(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n NR 17 SO 2 R 16 , —(CR 14 R 15 ) n OC(═Y′)R 16 , —(CR 14 R 15 ) n OC(═Y′)NR 16 R 17 , —(CR 14 R 15 ) n S(O)R 16 , —(CR 14 R 15 ) n S(O) 2 R 16 , —(CR 14 R 15 ) n S(O) 2 NR 16 R 17 , or R 16 ;
R 14 and R 15 are independently selected from H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 18 groups;
R 16 and R 17 are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 18 groups;
R 16 and R 17 are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 18 groups;
each R 18 is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —(CR 19 R 20 ) n C(═Y′)R 23 , —(CR 19 R 20 ) n C(═Y′)OR 23 , —(CR 19 R 20 ) n C(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n NR 23 R 24 , —(CR 19 R 20 ) n OR 23 , —(CR 19 R 20 ) n —SR 23 , —(CR 19 R 20 ) n NR 24 C(═Y′)R 23 , —(CR 19 R 20 ) n NR 24 C(═Y′)OR 23 , —(CR 19 R 20 ) n NR 22 C(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n NR 24 SO 2 R 23 , —(CR 19 R 20 ) n OC(═Y′)R 23 , —(CR 19 R 20 ) n OC(═Y′)NR 23 R 24 , —(CR 19 R 20 ) n S(O)R 23 , —(CR 19 R 20 ) n S(O) 2 R 23 , or —(CR 19 R 20 ) n S(O) 2 NR 23 R 24 , wherein said alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one to four R 21 groups;
R 19 and R 20 are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 25 groups;
R 23 and R 24 are independently H, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one to four R 21 groups;
R 23 and R 24 are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 21 groups;
each R 21 is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, CN, CF 3 , —OCF 3 , —NO 2 , oxo, —C(═Y′)R 25 , —C(═Y′)OR 25 , —C(═Y′)NR 25 R 26 , —NR 25 R 26 , —OR 25 , —SR 25 , —NR 26 C(═Y′)R 25 , —NR 26 C(═Y′)OR 25 , —NR 22 C(═Y′)NR 25 R 26 , —NR 26 SO 2 R 25 , —OC(═Y′)R 25 , —OC(═Y′)NR 25 R 26 , —S(O)R 25 , —S(O) 2 R 25 , or —S(O) 2 NR 25 R 26 , wherein said alkyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl are optionally substituted with one to four R 25 groups;
each R 25 and R 26 is independently H, alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one to four groups selected from halo, —CN, —OCF 3 , —CF 3 , —NO 2 , —C 1 -C 6 alkyl, —OH, oxo, —SH, —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —SO 2 (C 1 -C 6 alkyl), —CO 2 H, —CO 2 (C 1 -C 6 alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6 alkyl), —C(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)C(O)(C 1 -C 6 alkyl), —NHC(O)(C 1 -C 6 alkyl), —NHSO 2 (C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)SO 2 (C 1 -C 6 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6 alkyl), —SO 2 N(C 1 -C 6 alkyl) 2 , —OC(O)NH 2 , —OC(O)NH(C 1 -C 6 alkyl), —OC(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)NH(C 1 -C 6 alkyl), —NHC(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)C(O)NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)C(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)NH(C 1 -C 6 alkyl), —NHC(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)O(C 1 -C 6 alkyl), and —N(C 1 -C 6 alkyl)C(O)O(C 1 -C 6 alkyl);
R 25 and R 26 are optionally taken together with the attached N atom to form a 5-6 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four groups selected from halo, —CN, —OCF 3 , CF 3 , —NO 2 , —C 1 -C 6 alkyl, —OH, oxo, —SH, —O(C 1 -C 6 alkyl), —S(C 1 -C 6 alkyl), —NH 2 , —NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl) 2 , —SO 2 (C 1 -C 6 alkyl), —CO 2 H, —CO 2 (C 1 -C 6 alkyl), —C(O)NH 2 , —C(O)NH(C 1 -C 6 alkyl), —C(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)C(O)(C 1 -C 6 alkyl), —NHC(O)(C 1 -C 6 alkyl), —NHSO 2 (C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)SO 2 (C 1 -C 6 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1 -C 6 alkyl), —SO 2 N(C 1 -C 6 alkyl) 2 , —OC(O)NH 2 , —OC(O)NH(C 1 -C 6 alkyl), —OC(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)NH(C 1 -C 6 alkyl), —NHC(O)N(C 1 -C 6 alkyl) 2 , —N(C 1 -C 6 alkyl)C(O)NH(C 1 -C 6 alkyl), —N(C 1 -C 6 alkyl)C(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)NH(C 1 -C 6 alkyl), —NHC(O)N(C 1 -C 6 alkyl) 2 , —NHC(O)O(C 1 -C 6 alkyl), and —N(C 1 -C 6 alkyl)C(O)O(C 1 -C 6 alkyl);
Y′ is independently O, NR 22 , or S;
each R 22 is independently H or C 1 -C 5 alkyl; and
provided that (1) R 2 , R 3 , R 4 , R 5 , R 6 , and R 8 are not H at the same time; and (2) when X is CH, Y is CH, R 5 is H, Z is CR 8 , and R 3 is H or alkyl, then R 6 is not —C(═Y′)OR 11 .
2 . The compound of claim 1 wherein the compound is of Formula (I-a):
3 . The compound of claim 1 wherein the compound is of Formula (I-b):
4 . The compound of claim 3 wherein R 3 is H, CH 3 or halo.
5 . The compound of claim 4 wherein R 4 is —NR 11 R 12 or —OR 11 , wherein R 11 and R 12 are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13 groups.
6 . The compound of claim 5 wherein R 4 is selected from one of the following groups:
7 . The compound of claim 1 wherein R 5 is —NR 11 R 12 or —OR 11 , wherein R 11 and R 12 are optionally taken together with the attached N atom to form a 4-7 membered ring having additional 0-2 heteroatoms selected from O, S, and N, said ring being optionally substituted with one to four R 13 groups.
8 . The compound of claim 7 wherein R 5 is selected from one of the following groups:
9 . The compound of claim 1 wherein R 6 is H, CN or pyrrolyl optionally substituted with C 1 -C 3 alkyl.
10 . The compound of claim 1 wherein R 6 is H, CN, N-methylpyrrolyl, or pyrrolyl.
11 . The compound of claim 1 wherein R 6 is H or CN.
12 . The compound of claim 1 wherein R 6 is CN.
13 . A compound selected from the group consisting of:
4-(N-(morpholin-2-ylmethyl))-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(azetidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(quinuclidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1s,3s)-cyclobutanamine-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((piperidin-2-one)-5-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1,3-dimethylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(2-(pyrrolidin-1-ylmethyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(morpholin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(quinuclidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; trans-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-hydroxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-fluoro-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-methoxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1r,4r)-4-(dimethylamino)cyclohexyloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(4-methylmorpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-ethylpyrrolidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((1-ethylpyrrolidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; cis-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 1-[4-(3-Chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone (S)-3-Chloro-4-(3-hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(3-hydroxyazetidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(4-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-aminopyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(methylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Bromo-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Fluoro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((3-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(1-(3-fluoropropyl)-4-methylpiperidin-4-yl)methoxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-(2-hydroxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-(2-methoxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-ethyl-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-1-ethylpiperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-(2-hydroxyethyl)piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-(2-methoxyethyl)piperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-ethyl-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-ethylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-ethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 4-(4-(pyrrolidin-3-yl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(N-methylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 4-(octahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 4-((3 aS,6 aS)-1-methyloctahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-piperidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 3-chloro-4-piperazin-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(1-ethylpiperazin)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(2,2-difluoro ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(pyrrolidin-3-yl)isobutyramide)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(2,2,2-trifluoroethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b; 4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(Piperidin-3-yloxy)-6-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole; 1-[4-(9H-Dipyrido[2,3b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone; [(S)-1-(9H-Dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-pyrrolidin-3-yl]-ethyl-amine; 4-(1-Ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-[(S)-(1-Azabicyclo-[2.2.2]oct-3-yl)oxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((S)-1-Ethylpiperidin-3-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; cis-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Ethylpiperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Pyrrolidin-1-ylpiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3b;4′,3′ d]pyrrole-6-carbonitrile; 4-((R)-1-Ethyl-piperidin-3-ylamino)-9H-dipyrido-[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Methylaminopiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 4-((S)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; Trans-3-Fluoropiperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′d]pyrrole-6-carbonitrile; 5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile; 5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Ethylamino-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1,3′]Bipyrrolidinyl-1′-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6carbonitrile; 5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile; 5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and 5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.
14 . The compound of claim 13 , where in said compound is selected from the group consisting of:
4-(N-(morpholin-2-ylmethyl))-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(azetidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(morpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(quinuclidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1s,3s)-cyclobutanamine-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((1-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((4-methylpiperazin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((piperidin-2-one)-5-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1,3-dimethylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(2-(pyrrolidin-1-ylmethyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(morpholin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(quinuclidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; trans-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1R,3S,4S)-2-azabicyclo[2.2.1]heptan-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(2-((dimethylamino)methyl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(2-((methylamino)methyl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-hydroxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-fluoro-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-methoxy-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(3-(dimethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1r,4r)-4-(dimethylamino)cyclohexyloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperidin-3-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(4-methylmorpholin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-ethylpyrrolidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-((1-ethylpyrrolidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(3-(ethylamino)piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(4-(2-(pyrrolidin-2-yl)acetyl)piperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; cis-4-(4-fluoropiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 1-[4-(3-Chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone (S)-3-Chloro-4-(3-hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((3S,4S)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-((3R,4R)-3,4-dihydroxypyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(3-hydroxyazetidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-3-Chloro-4-(3-hydroxy-3-methylpyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-3-Chloro-4-(3-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(4-hydroxypiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-aminopyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(methylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Bromo-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Fluoro-4-(3-(ethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((3-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(3-(dimethylamino)-2,2-dimethylpropoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(1-(3-fluoropropyl)-4-methylpiperidin-4-yl)methoxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-(2-hydroxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-carbonitrile; 4-((1-(2-methoxyethyl)-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1-ethyl-4-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-methylpiperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-1-ethylpiperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-(2-hydroxyethyl)piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(1-(2-methoxyethyl)piperidin-3-oxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((4-ethyl-1-methylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((1,4-dimethylpiperidin-4-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(piperidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-ethylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-((1-methylpiperidin-2-yl)methoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(N-(2-methoxyethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N-ethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-(pyrrolidin-3-yl)morpholino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(2,5-diazabicyclo[2.2.1]heptan-2-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(N-methylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-4-(N,N-dimethylpyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(octahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((3aS,6aS)-1-methyloctahydropyrrolo[3,4-b]pyrrol)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-piperidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-chloro-4-piperazin-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-4-(1-ethylpiperazin)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(3-fluoropropyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(3-(2,2-difluoroethylamino)pyrrolidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(pyrrolidin-3-yl)isobutyramide)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (S)-3-Chloro-4-(N-(2,2,2-trifluoroethyl)pyrrolidin-3-amino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; (R)-4-(Piperidin-3-yloxy)-6-(1-methyl-1H-pyrazol-4-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole; 1-[4-(9H-Dipyrido[2,3b;4′,3′-d]pyrrol-4-yl)-piperazin-1-yl]-2-(R)-pyrrolidin-2-yl-ethanone; [(S)-1-(9H-Dipyrido[2,3-b;4′,3′-d]pyrrol-4-yl)-pyrrolidin-3-yl]-ethyl-amine; 4-(1-Ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-[(S)-(1-Azabicyclo-[2.2.2]oct-3-yl)oxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((S)-1-Ethylpiperidin-3-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; cis-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Ethylpiperazin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Pyrrolidin-1-ylpiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3b;4′,3′ d]pyrrole-6-carbonitrile; 4-((R)-1-Ethyl-piperidin-3-ylamino)-9H-dipyrido-[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 4-(4-Methylaminopiperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 4-((R)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 4-((S)-3-Hydroxypyrrolidin-1-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; and Trans-3-Fluoropiperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′d]pyrrole-6-carbonitrile.
15 . The compound of claim 13 , wherein said compound selected from the group consisting of:
5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile; 5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Ethylamino-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1,3′]Bipyrrolidinyl-1′-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6carbonitrile; 5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile; 5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and 5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.
16 . The compound of claim 13 , wherein said compound selected from the group consisting of:
5-(Piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Pyrrolidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-Piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((R)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(Cis)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Pyrrolidin-2-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Butyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(2-Pyrrolidin-1-yl-ethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(trans)-3-Fluoro-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3-Fluoro-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Aza-bicyclo[2.2.2]oct-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1,4-Dimethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-oxetan-3-yl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-fluoro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)oxy]-3-chloro-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′ d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-((S)-1-Ethyl-piperidin-3-ylmethoxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-azepan-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxy-2-methyl-propyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-azetidin-3-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-methyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2,2-Difluoroethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Methanesulfonylethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Hydroxyethyl)-piperidin-4-yloxy]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Ethyl-piperidin-4-yloxy)-3-methyl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and 5-(1-Ethyl-piperidin-4-yloxy)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole.
17 . The compound of claim 13 , wherein said compound selected from the group consisting of:
5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(2-Methoxy-ethyl)-piperidin-4-ylamino]-9Hdipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(1-Ethyl-piperidin-4-yl)-methyl-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[1-(3,3,3-Trifluoro-propyl)-piperidin-4-ylamino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(S)-(1-Azabicyclo[2.2.2]oct-3-yl)amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[(4-Ethyl-morpholin-2-ylmethyl)-amino]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Oxetan-3-yl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Cyclopropylmethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(1-ethyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(1-Methyl-piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and 5-(Piperidin-4-ylamino)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile.
18 . The compound of claim 13 , wherein said compound selected from the group consisting of:
5-[4-(3-Fluoro-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-(3-Hydroxy-azetidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((S)-3-Fluoro-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Azetidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Fluoropyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((S)-3-Hydroxypyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-[4-((R)-3-Hydroxy-pyrrolidin-1-yl)-piperidin-1-yl]-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-[1,4]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Fluoro-[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Hydroxy-4-methyl[1,4′]bipiperidinyl-1′-yl)-9H-dipyrido[2,3b;4′,3′-d]pyrrole-6-carbonitrile; 3-Fluoro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Bromo-5-(4-morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 3-Chloro-5-(4-pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Pyrrolidin-1-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; 5-(4-Morpholin-4-yl-piperidin-1-yl)-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6-carbonitrile; and 5-piperazin-1-yl-9H-dipyrido[2,3-b;4′,3′-d]pyrrole-6 carbonitrile.
19 . A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
20 . The pharmaceutical composition of claim 19 , further comprising a second chemotherapeutic agent.
21 . The pharmaceutical composition of claim 20 , wherein said second chemotherapeutic agent is a DNA damaging agent.
22 . A method of inhibiting abnormal cell growth or treating a hyperproliferative disorder in a mammal comprising administering to said mammal a therapeutically effective amount of a pharmaceutical composition of claim 19 .
23 . The method of treating cancer in a mammal comprising administering to said mammal a therapeutically effective amount of a pharmaceutical composition of claim 19 .
24 . The method of claim 23 , wherein cancer is selected from breast cancer, colorectal cancer, ovarian cancer, non-small cell lung cancer, malignant brain tumors, sarcomas, melanoma, lymphoma, myelomas and leukemia.Cited by (0)
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