Composition for preventing and healing osteonecrosis of the jaw

Abstract

A composition for preventing and treating all forms of osteonecrosis of the jaw are disclosed. The composition is comprised of 0.005%-2.0% weight/volume (w/v) chlorine dioxide source, such as sodium chlorite, chlorite ion, stabilized chlorine dioxide or similar and may take the form of a paste, gel, rinse, spray, powder, varnish or similar. The prevention and treatment includes the application of the composition in the oral cavity and other body areas affected by osteonecrosis of the jaw.

We claim: 
     
         1 . A composition for arresting and healing osteonecrosis of the jaw (ONJ) with a non-invasive procedure, said composition comprising:
 (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;   (b) said composition having an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;   (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;   (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ; and   (e) said composition non-invasively debriding oral tissue affected by ONJ.   
     
     
         2 . The composition as set forth in  claim 1  wherein said composition is in the form of a gel. 
     
     
         3 . The composition as set forth in  claim 1  wherein the weight/volume (w/v) of the chlorine dioxide source is 0.10%. 
     
     
         4 . The composition as set forth in  claim 1  wherein the diseased area becomes closed with no bone exposure. 
     
     
         5 . A composition for penetrating, controlling and eliminating the biofilm associated with osteonecrosis of the jaw (ONJ), said composition comprising:
 (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;   (b) said composition producing an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;   (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;   (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ; and   (e) said composition non-invasively debriding oral tissue affected by ONJ.   
     
     
         6 . The composition as set forth in  claim 5  wherein said composition is in the form of a gel. 
     
     
         7 . The composition as set forth in  claim 5  wherein the weight/volume (w/v) of the chlorine dioxide source is 0.10%. 
     
     
         8 . The composition as set forth in  claim 5  wherein the diseased area becomes closed with no bone exposure. 
     
     
         9 . A composition for treating and arresting bisphosphonate-related osteonecrosis of the jaw (ONJ), said composition comprising:
 (a) an alcohol free composition for application to ONJ tissues and lesions comprising a solution of a chlorine dioxide source having a concentration in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide;   (b) said composition producing an antimicrobial effect against free-floating microorganisms that are present in lesions and tissues affected by ONJ;   (c) said composition penetrating, controlling or eliminating biofilm that forms over tissues affected by or susceptible to ONJ;   (d) said composition producing an antimicrobial effect against microorganisms present in biofilm formed over tissues affected by or susceptible to ONJ; and   (e) said composition non-invasively debriding oral tissue affected by ONJ.   
     
     
         10 . The composition as set forth in  claim 9  wherein said composition is in the form of a gel. 
     
     
         11 . The composition as set forth in  claim 9  wherein the weight/volume (w/v) of the chlorine dioxide source is 0.10%. 
     
     
         12 . The composition as set forth in  claim 9  wherein the diseased area becomes closed with no bone exposure. 
     
     
         13 . A composition for preventing osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide. 
     
     
         14 . The composition as set forth in  claim 13  wherein the composition is in the form of a rinse. 
     
     
         15 . The composition as set forth in  claim 13  wherein the composition is in the form of a gel. 
     
     
         16 . The composition as set forth in  claim 13  wherein the composition is in the form of a paste. 
     
     
         17 . The composition as set forth in  claim 13  wherein the composition is in the form of a spray. 
     
     
         18 . The composition as set forth in  claim 13  wherein the composition is in the form of a powder. 
     
     
         19 . A composition for healing osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide. 
     
     
         20 . The composition as set forth in  claim 19  wherein the composition is in the form of a rinse. 
     
     
         21 . The composition as set forth in  claim 19  wherein the composition is in the form of a gel. 
     
     
         22 . The composition as set forth in  claim 19  wherein the composition is in the form of a paste. 
     
     
         23 . The composition as set forth in  claim 19  wherein the composition is in the form of a spray. 
     
     
         24 . The composition as set forth in  claim 19  wherein the composition is in the form of a powder. 
     
     
         25 . A composition for preventing, controlling and eliminating the biofilm associated with osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide. 
     
     
         26 . A composition for treating and preventing bisphosphonate associated osteonecrosis of the jaw, said composition comprising a solution of chlorine dioxide in the range of about 0.005% to about 2.0% weight/volume (w/v) selected from the group consisting of sodium chlorite, chlorite ion, and stabilized chlorine dioxide.