Pyrrolidine-1,2-dicarboxamide derivatives

Abstract

The present invention relates to a compound of formula (I) or a salt thereof, wherein the substituents are as defined in the description, to compositions and use of the compounds in the treatment of diseases ameloriated by inhibition of phosphatidylinositol 3-kinase.

1 . A method of treatment of a cancer of the breast or a tumor of the head or neck comprising administering to a subject in need thereof a therapeutically effective amount of a compound (S)-pyrrolidine-1,2-dicarboxylic acid 2-amide 1-({4-methyl-5-[2-(2,2,2-trifluoro-1,1-dimethyl-ethyl)-pyridin-4-yl]-thiazol-2-yl}-amide) or a pharmaceutically acceptable salt thereof and a therapeutically effective amount of an anticancer agent selected from the group consisting of fulvestrant, paclitaxel, cisplatin, vinblastine, tamoxifen, oxaliplatin, or a pharmaceutically acceptable salt thereof. 
     
     
         2 . The method according to  claim 1 , wherein the anticancer agent is fulvestrant or a pharmaceutically acceptable salt thereof. 
     
     
         3 . The method according to  claim 1 , wherein the anticancer agent is paclitaxel or a pharmaceutically acceptable salt thereof.