Methods and devices for compound delivery

Abstract

Provided herein are methods, devices, systems, and computer readable medium for delivering one or more compounds to a subject. Also described herein are methods, devices, systems, and computer readable medium for transitioning a smoker to an electronic nicotine delivery device and for smoking or nicotine cessation.

1 . A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising:
 a. a reservoir comprising a liquid formulation; and   b. a passageway comprising a heater element, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the passageway condenses the vaporized liquid formulation into particles having a mass median aerodynamic diameter (MMAD) of from about 1 μm to about 5 μm.   
     
     
         2 . The device of  claim 1 , wherein the device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H 2 O)/LPM. 
     
     
         3 . The device of  claim 1 , wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air. 
     
     
         4 . The device of  claim 3 , wherein the heater element is located within the passageway between the upstream and downstream openings. 
     
     
         5 . The device of  claim 3 , wherein the reservoir is located within the passageway between the upstream and downstream openings. 
     
     
         6 . The device of  claim 3 , further comprising an air flow regulator located in the passageway. 
     
     
         7 . The device of  claim 6 , further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. 
     
     
         8 . The device of  claim 8 , wherein the air flow regulator comprises one or more gas control valves. 
     
     
         9 . The device of  claim 1 , wherein the heater element comprises a wire coil. 
     
     
         10 . The device of  claim 1 , further comprising a capillary in fluid communication with the reservoir. 
     
     
         11 . The device of  claim 10 , wherein the capillary is in fluid communication with the heater element. 
     
     
         12 . The device of  claim 10 , wherein the capillary comprises a heatable region. 
     
     
         13 . The device of  claim 12 , further comprising a check valve located in the capillary between the heatable region and the reservoir. 
     
     
         14 . The device of  claim 1 , further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. 
     
     
         15 . The device of  claim 14 , further comprising an interface for communicating with the controller. 
     
     
         16 . The device of  claim 14 , wherein the controller is removably attached to the passageway and the reservoir. 
     
     
         17 . The device of  claim 14 , wherein the controller is capable of communicating with one or more electronic devices. 
     
     
         18 . The device of  claim 1 , wherein the liquid formulation comprises a flavoring. 
     
     
         19 . A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising:
 a. a passageway comprising a heater element; and   b. a reservoir comprising the liquid formulation, wherein the reservoir is in fluid communication with the heater element, wherein the heater element is capable of vaporizing the liquid formulation when the liquid formulation is delivered onto the heater element, and wherein a flow of air through the device delivers the condensation aerosol of the liquid formulation to the deep lung of a subject using the device.   
     
     
         20 . The device of  claim 19 , wherein the device permits a flow resistance of from about 0.08 to about 0.12 sqrt (cm-H 2 O)/LPM. 
     
     
         21 . The device of  claim 19 , wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for the air, and wherein the heater element is located in the passageway between the upstream and downstream openings. 
     
     
         22 . The device of  claim 19 , wherein the reservoir is located within the passageway between the upstream and downstream openings. 
     
     
         23 . The device of  claim 19 , further comprising an air flow regulator located in the passageway. 
     
     
         24 . The device of  claim 23 , further comprising a second passageway, wherein the air flow regulator is capable of directing the air through the second passageway in response to a pressure drop across the air flow regulator. 
     
     
         25 . The device of  claim 24 , wherein the air flow regulator comprises one or more gas control valves. 
     
     
         26 . The device of  claim 19 , wherein the heater element comprises a wire coil. 
     
     
         27 . The device of  claim 19 , further comprising a capillary in fluid communication with the reservoir. 
     
     
         28 . The device of  claim 27 , wherein the capillary is in fluid communication with the heater element. 
     
     
         29 . The device of  claim 27 , wherein the capillary comprises a heatable region. 
     
     
         30 . The device of  claim 19 , further comprising a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. 
     
     
         31 . The device of  claim 30 , further comprising an interface for communicating with the controller. 
     
     
         32 . The device of  claim 30 , wherein the controller is removably attached to the passageway and the reservoir. 
     
     
         33 . The device of  claim 30 , wherein the controller is capable of communicating with one or more electronic devices. 
     
     
         34 . The device of  claim 19 , wherein the liquid formulation comprises a flavoring. 
     
     
         35 . A method of administering a condensation aerosol to a deep lung of a subject, the method comprising:
 a. generating a condensation aerosol, wherein the generating comprises vaporizing a liquid formulation delivered onto a heater element, wherein the heater element is located in a passageway of a condensation aerosol generating device, wherein the condensation aerosol has an MMAD of from about 1 μm to about 5 μm; and   b. flowing a gas through the condensation aerosol generating device to deliver the condensation aerosol to a deep lung of a subject using the device.   
     
     
         36 . The method of  claim 35 , wherein the condensation aerosol generating device is configured to produce an internal air resistance of from about 0.08 to about 0.12 sqrt (cm-H 2 O)/LPM. 
     
     
         37 . The method of  claim 35 , wherein the passageway comprises an upstream opening and a downstream opening, wherein the upstream opening comprises an inlet for the air and the downstream opening serves as an outlet for air. 
     
     
         38 . The method of  claim 37 , wherein the heater element is located within the passageway between the upstream and downstream openings. 
     
     
         39 . The method of  claim 37 , wherein the condensation aerosol generating device further comprises a reservoir located within the passageway between the upstream and downstream openings. 
     
     
         40 . The method of  claim 35 , wherein the condensation aerosol generating device further comprises an air flow regulator located in the passageway. 
     
     
         41 . The method of  claim 40 , wherein the condensation aerosol generating device further comprises a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. 
     
     
         42 . The method of  claim 41 , wherein the air flow regulator comprises one or more gas control valves. 
     
     
         43 . The method of  claim 37 , wherein the heater element comprises a wire coil. 
     
     
         44 . The method of  claim 37 , wherein the condensation aerosol generating device further comprises a capillary in fluid communication with the reservoir. 
     
     
         45 . The method of  claim 44 , wherein the capillary is in fluid communication with the heater element. 
     
     
         46 . The method of  claim 44 , wherein the capillary comprises a heatable region. 
     
     
         47 . The method of  claim 46 , wherein the condensation aerosol generating device further comprises a check valve located in the capillary between the heatable region and the reservoir. 
     
     
         48 . The method of  claim 35 , wherein the condensation aerosol generating device further comprises a controller, wherein the controller comprises a non-transitory computer readable medium comprising one or more algorithms, wherein the one or more algorithms regulate dosing or a delivery schedule of the condensation aerosol of the liquid formulation. 
     
     
         49 . The method of  claim 48 , wherein the condensation aerosol generating device further comprises an interface for communicating with the controller. 
     
     
         50 . The method of  claim 48 , wherein the controller is removably attached to the passageway and the reservoir. 
     
     
         51 . The method of  claim 48 , wherein the controller is capable of communicating with one or more electronic devices. 
     
     
         52 . A condensation aerosol generating device for generating a condensation aerosol of a liquid formulation, the device comprising: a passageway comprising a heater element, an inlet, and an outlet, wherein the heater element is located between the inlet and the outlet of the passageway, wherein the passageway is adapted to produce a condensation aerosol from a liquid formulation delivered onto the heater element, and wherein the device is configured to produce an internal air resistance that is no greater than that of a cigarette. 
     
     
         53 . The device of  claim 52 , wherein the internal air resistance is at most 0.20 sqrt (cm-H 2 O)/LPM. 
     
     
         54 . The device of  claim 52 , wherein the internal air resistance is from about 0.08 to about 0.12 sqrt (cm-H 2 O)/LPM. 
     
     
         55 . The device of  claim 52 , further comprising a reservoir in fluid communication with the heater element. 
     
     
         56 . The device of  claim 52 , wherein the device further comprises an air flow regulator located in the passageway. 
     
     
         57 . The device of  claim 56 , further comprising a second passageway, wherein the air flow regulator is capable of directing air through the second passageway in response to a pressure drop across the air flow regulator. 
     
     
         58 . The device of  claim 57 , wherein the air flow regulator comprises one or more gas control valves. 
     
     
         59 . The device of  claim 52 , wherein the heater element comprises a wire coil. 
     
     
         60 . The device of  claim 52 , wherein the device is configured to detect inhalation from a user. 
     
     
         61 . The device of  claim 60 , wherein the device is further configured to produce the condensation aerosol within 1000 milliseconds from the detection of inhalation from the user. 
     
     
         62 . The device of  claim 61 , wherein the condensation aerosol is present in the first third of the volume of air inhaled by the user. 
     
     
         63 . The device of  claim 52 , wherein the liquid formulation comprises nicotine.