Crushed bacterial body and compositions thereof

Abstract

A crushed bacterial body can be obtained by culturing a gram-negative bacterium and physically crushing a body of the gram-negative bacterium, comprises all components including immunostimulatory components in the bacterial body, and comprises LPSs having molecular weights of 20,000 or less as active ingredients. The crushed bacterial body is effective as a health food, drug, skin-care product, bath agent, feedstuff for protecting crustaceans, shellfish, fish, poultry, farm animals and pet animals from infections, and a feed additive for growth promotion, and can provide an innate immunostimulatory substance derived from a gram-negative bacterial body having infection-preventing effects and growth promoting effects, an inexpensive and practical microbial crushed bacterial body, and a composition thereof.

1 . A crushed bacterial body which can be obtained by culturing a gram-negative  bacterium  and physically crushing a body of the gram-negative  bacterium  after the body was heated, comprises all components including immunostimulatory components in the bacterial body after the body was heated, and comprises LPSs having molecular weights of 20,000 or less as active ingredients. 
     
     
         2 . The crushed bacterial body according to  claim 1 , wherein the gram-negative  bacterium  is  Escherichia coli, Serratia bacterium, Aeromonas bacterium, Rahnella bacterium, Enterobacter bacterium, Xanthomonas bacterium, Zymomonas bacterium, Pantoea bacterium  or  Acetobacter bacterium.    
     
     
         3 . A composition of the crushed bacterial body contains the crushed bacterial body according to  claim 1  wherein said composition is selected from a pharmaceutical, quasi drug, cosmetic, food, functional food, bath agent, feedstuff, pet food or veterinary drug. 
     
     
         4 . A composition of the crushed bacterial body contains the crushed bacterial body according to  claim 1  wherein said composition is selected from a fertilizer, a compost or a pharmaceutical for plants. 
     
     
         5 . The composition according to  claim 3  which is intended for growth promotion, immune activation, prevention of lifestyle-related diseases, cancers or allergic diseases, infection prevention, or stress resistance. 
     
     
         6 . The composition according to  claim 4  which is intended for growth promotion, immune activation, infection prevention or stress resistance. 
     
     
         7 . A composition of the crushed bacterial body contains the crushed bacterial body according to  claim 2  wherein said composition is selected from a pharmaceutical, quasi drug, cosmetic, food, functional food, bath agent, feedstuff, pet food or veterinary drug. 
     
     
         8 . A composition of the crushed bacterial body contains the crushed bacterial body according to  claim 2  wherein said composition is selected from a fertilizer, a compost or a pharmaceutical for plants. 
     
     
         9 . The composition according to  claim 7  which is intended for growth promotion, immune activation, prevention of lifestyle-related diseases, cancers or allergic diseases, infection prevention, or stress resistance. 
     
     
         10 . The composition according to  claim 8  which is intended for growth promotion, immune activation, infection prevention or stress resistance.