Gateway platform for biological monitoring and delivery of therapeutic compounds

Abstract

The invention relates to methods and devices for remote or distributed continuous monitoring of physiologically relevant states. The invention provides for methods to automatically detect deviations or other states in physiological parameters and automatically alert a measured subject, user or other authorized party. The device provides for a universal platform for sensors, and further provides for the automatic compensation or distribution of devices or bioactive agents at appropriate levels and/or intervals in response to deviations or other states sensed in various physiological parameters.

1 . A system for monitoring physiological status of a mammalian subject, comprising:
 at least one biointerface head (BIH), said at least one BIH being attached to an external surface of said subject and configured to communicate data and a BIH identifier;   at least one control and communication module (CCM) storing a CCM identifier and which is linked to at least one biointerface head to receive said data and said BIH identifier, wherein said control and communication module receives data from at least one biointerface head;   at least one data collection unit (DCU) which receives data and said identifiers from the control and communication module; and   a remote database management system which receives data from at least one data collection unit and processes said data.   
     
     
         2 . The system of  claim 1 , wherein said BIH comprises a device for therapeutic compound delivery. 
     
     
         3 . The system of  claim 1 , wherein said BIH comprises a physiological parameter sensor. 
     
     
         4 . The system of  claim 1 , wherein said biointerface head is attached to said mammalian subject with at least one adhesive. 
     
     
         5 . The system of  claim 1 , wherein said control and communication module is attached to said mammalian subject with at least one adhesive. 
     
     
         6 . The system of  claim 1 , wherein said system comprises a transdermal conduit and a biofluid access port, and wherein the transdermal conduit and biofluid access port are coated with a hydrogel material. 
     
     
         7 . The system of  claim 1 , wherein said system further comprises a chamber which releases one or more therapeutic agents. 
     
     
         8 . The system of  claim 1 , wherein said data collection unit processes information before sending information to said remote data management system. 
     
     
         9 . The system of  claim 1 , wherein the data management system provides feedback to the data collection unit and/or the communication module. 
     
     
         10 . The system of  claim 1 , wherein said feedback comprises diagnostic knowledge. 
     
     
         11 . The system of  claim 1 , wherein said feedback comprises actions and/or instructions. 
     
     
         12 . The system of  claim 1 , comprising a plurality of communication modules. 
     
     
         13 . The system of  claim 1 , comprising a plurality of data collection units. 
     
     
         14 . The system of  claim 1 , wherein data is transmitted from a BIH, through a plurality of CCMs, to a DCU. 
     
     
         15 - 27 . (canceled)