Cyclodextrin-based materials compositions and uses related thereto

Abstract

This application discloses cyclodextrin-modified materials for carrying drugs and other active agents, such as nucleic acids. Compositions are also disclosed of cyclodextrin-modified materials that release such active agents under controlled conditions. The invention also discloses compositions of cyclodextrin-modified polymer carriers that are coupled to biorecognition molecules for assisting the delivery of drugs to their site of action.

1 . A polymer composition comprising a linear biocompatible polymer including a plurality of inclusion hosts, and linking molecules, each linking molecule comprising at least two moieties that form inclusion complexes with the inclusion hosts, wherein the linking molecules crosslink the polymer. 
     
     
         2 . A polymer composition of  claim 1 , wherein the inclusion hosts are cyclodextrin moieties. 
     
     
         3 . A polymer composition of  claim 1 , further comprising at least one biologically active compound or a prodrug form thereof. 
     
     
         4 . A polymer composition of  claim 3 , wherein the biologically active compound is a nucleic acid. 
     
     
         5 . A polymer composition of  claim 4 , wherein the nucleic acid is provided in a delivery system selected from a virus, a polymer, and a liposome. 
     
     
         6 . A method for transfecting a cell with a nucleic acid, comprising contacting the cell with a polymer composition of  claim 4 . 
     
     
         7 . A polymer composition of  claim 3 , wherein the compound is a polypeptide or a small organic molecule. 
     
     
         8 . A method for administering a biologically active compound to a patient, comprising administering to the patient a polymer composition of  claim 3 . 
     
     
         9 . A polymer composition of  claim 3 , wherein the compound is a protein or polypeptide. 
     
     
         10 . A polymer composition of  claim 3 , wherein the biologically active compound or prodrug form thereof is provided in a delivery system. 
     
     
         11 . A polymer composition of  claim 10 , wherein the delivery system is selected from microparticles and liposomes. 
     
     
         12 . A polymer composition of  claim 3 , wherein the biologically active compound is covalently attached to a moiety that forms an inclusion complex with the inclusion host. 
     
     
         13 . A polymer composition of  claim 1 , further comprising at least one adjuvant. 
     
     
         14 . A polymer composition of  claim 3 , further comprising an adjuvant that increases the effectiveness of the biologically active agent. 
     
     
         15 . A polymer composition comprising a biocompatible, biodegradable polymer including a plurality of inclusion hosts, and linking molecules, each linking molecule comprising at least two moieties that form inclusion complexes with the inclusion hosts, wherein the linking molecules crosslink the polymer. 
     
     
         16 .- 17 . (canceled) 
     
     
         18 . A therapeutic composition comprising a) a biocompatible polymer including a plurality of inclusion hosts, b) linking molecules, each linking molecule comprising at least two moieties that form inclusion complexes with the inclusion hosts, and c) a therapeutic agent, wherein the linking molecules crosslink the polymer. 
     
     
         19 .- 30 . (canceled)