US2014206631A1PendingUtilityA1

Cardiac Glycoside Analogs in Combination with Emodin for Cancer Therapy

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Assignee: SIRBAL LTDPriority: Nov 13, 2010Filed: Sep 23, 2013Published: Jul 24, 2014
Est. expiryNov 13, 2030(~4.3 yrs left)· nominal 20-yr term from priority
Inventors:Nadav Shraibom
A61P 43/00A61K 31/7048A61K 36/72A61K 36/708A61P 35/02A61K 36/704A61P 35/00A61K 45/06A61K 31/122
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Claims

Abstract

A method and medicine for treating leukemia or other cancer includes administering to a patient diagnosed with leukemia or other cancer a treatment regimen that includes periodic doses of a combination of emodin and digoxin.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method of preparing medicine for treating leukemia, melanoma, or colon, prostate or breast cancer, comprising preparing a combination including an effective amount of digoxin with 5 ug/ml or more of emodin. 
     
     
         2 . The method of  claim 1 , wherein the combination comprises approximately 10 g/ml or more of emodin. 
     
     
         3 . The method of  claim 1 , wherein the combination comprises approximately 0.05 ug/ml or more of digoxin. 
     
     
         4 . The method of  claim 1 , wherein the combination comprises approximately 0.10 ug/ml or more of digoxin. 
     
     
         5 . The method of  claim 1 , wherein the combination comprises approximately 10 ug/ml or more of emodin and approximately 0.10 ug/ml or more of digoxin. 
     
     
         6 . The method of  claim 1 , wherein the combination comprises approximately 10 ug/ml or more of emodin and approximately 0.05 ug/ml or more of digoxin. 
     
     
         7 . The method of  claim 1 , comprising preparing an aqueous solution including cooking emodin- and digoxin-containing herbs in water. 
     
     
         8 . The method of  claim 1 , comprising extracting the emodin from rhubarb root. 
     
     
         9 . The method of  claim 1 , comprising extracting the emodin from rhubarb. 
     
     
         10 . The method of  claim 1 , comprising extracting the emodin from Buckthorn. 
     
     
         11 . The method of  claim 1 , comprising extracting the emodin from Japanese Knotweed. 
     
     
         12 . A medicine for treating leukemia, melanoma, or colon, prostate or breast cancer, comprising a combination of an effective amount of digoxin with approximately 5 ug/ml or more of emodin. 
     
     
         13 . The medicine of  claim 12 , comprising approximately 10 g/ml or more of emodin. 
     
     
         14 . The medicine of  claim 12 , comprising approximately 0.05 ug/ml or more of digoxin. 
     
     
         15 . The medicine of  claim 12 , comprising approximately 0.1 ug/ml or more of digoxin. 
     
     
         16 . The medicine of  claim 12 , comprising approximately 10 ug/ml or more of emodin and approximately 0.10 ug/ml or more of digoxin. 
     
     
         17 . The medicine of  claim 12 , comprising approximately 10 g/ml or more of emodin and approximately 0.05 ug/ml or more of digoxin. 
     
     
         18 . The medicine of  claim 12 , comprising a pharmaceutically acceptable carrier. 
     
     
         19 . The medicine of  claim 18 , wherein the carrier comprises water. 
     
     
         20 . The medicine of  claim 18 , wherein the carrier comprises DMSO.

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