US2014206852A1PendingUtilityA1

Signal-sensor polynucleotides

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Assignee: MODERNA THERAPEUTICS INCPriority: Jan 17, 2013Filed: Dec 20, 2013Published: Jul 24, 2014
Est. expiryJan 17, 2033(~6.5 yrs left)· nominal 20-yr term from priority
Inventors:Stephen HogeAntonin De FougerollesTirtha Chakraborty
A61P 35/00A61P 35/02A61K 31/7105C12N 15/85C12N 2310/141C07K 14/47A61K 48/0058A61K 38/00C12N 15/113A61K 31/711
61
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Claims

Abstract

The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of signal-sensor polynucleotides, primary transcripts and mmRNA molecules.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . An isolated synthetic signal-sensor polynucleotide, wherein said isolated synthetic signal-sensor polynucleotide comprises an mRNA which encodes an oncology-related polypeptide of interest and a sensor sequence comprising SEQ ID NO: 3741. 
     
     
         2 . The isolated synthetic signal-sensor polynucleotide of  claim 1 , wherein the open reading frame of the mRNA is codon optimized. 
     
     
         3 . The isolated synthetic signal-sensor polynucleotide of  claim 1 , wherein the isolated synthetic signal-sensor polynucleotide comprises at least one chemical modification, wherein the chemical modification is 1-methylpseudouridine. 
     
     
         4 . The isolated synthetic signal-sensor polynucleotide of  claim 3 , further comprising the chemical modification 5-methylcytidine.

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