Membrane system with sufficient buffering capacity

Abstract

Electrochemical sensors for measurement of an analyte comprising an analyte sensing membrane comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof. Sensor testing methods comprising contacting an electrochemical sensor with an aqueous solution comprising at least one salt of acetate ion, carbonate ion, bicarbonate ion, or mixtures thereof and contacting the electrochemical sensor with one or more concentrations of analyte, the one or more concentrations of analyte being in the clinical concentration range of the analyte.

What is claimed is: 
     
         1 . An electrochemical analyte sensor comprising:
 at least one electrode having an electroactive surface;   an analyte sensing membrane, at least a portion of the membrane covering the electroactive surface, the membrane comprising:   an optional interference layer;   an enzyme layer;   an optional hydrophilic polymer layer positioned (i) between the electroactive surface and the interference layer and/or (ii) between the interference layer and the enzyme layer; and   at least one buffering agent associated with the analyte sensing membrane,   wherein the buffering agent comprises at least one salt of acetate ion, carbonate ion, bicarbonate ion, or combinations thereof.