US2014212969A1PendingUtilityA1

Nucleic Acids, Polypetides, and Methods for Modulating Apoptosis

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Assignee: SENESCO TECHNOLOGIES INCPriority: Jul 23, 2001Filed: Oct 11, 2013Published: Jul 31, 2014
Est. expiryJul 23, 2021(expired)· nominal 20-yr term from priority
Inventors:Catherine TaylorTzann-Wei WangLarry PetrovJohn C. CarlsonRichard NarayansinghJohn E. Thompson
A61P 9/10A61P 37/06A61P 37/04A61P 43/00A61P 37/02A61P 9/04A61P 3/10A61P 37/08A61P 35/04A61P 9/00A61P 25/08A61P 31/12A61P 27/02A61P 29/00A61P 27/06A61P 31/04A61P 31/18A61P 35/00A61P 35/02A61P 25/14A61P 25/00A61P 25/28A61P 25/16C07K 14/4747A61P 11/06A61P 13/12C12Q 2600/158A61P 17/00C12N 15/1137A61P 13/10C12Q 1/6876A61P 19/10A61P 21/04C12N 9/0004A61P 17/02A61P 19/02C12N 15/1136C12N 15/11C07K 14/47A61K 48/00A61P 1/16
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Claims

Abstract

The present invention relates to isolated and/or purified rat apoptosis-specific eucaryotic initiation Factor-5A (eIF-5A) and deoxyhypusine synthase (DHS) nucleic acids and polypeptides. The present invention also relates to methods of modulating apoptosis using apoptosis-specific eIF-5A and DHS, and antisense oligonucleotides and expression vectors of apoptosis-specific and DHS useful in such methods.

Claims

exact text as granted — not AI-modified
1 - 63 . (canceled) 
     
     
         64 . A method of inhibiting apoptosis in a cell comprising administering to the cell an oligonucleotide that is antisense to the 3′-UTR of a mammalian nucleic acid molecule encoding apoptosis-specific eIF-5A, wherein the antisense oligonucleotide inhibits apoptosis-specific eIF-5A expression. 
     
     
         65 . The method of  claim 64 , wherein the nucleic acid molecule comprises SEQ ID NO:3. 
     
     
         66 . The method of  claim 64 , wherein the nucleic acid molecule consists of SEQ ID NO:3. 
     
     
         67 . The method of  claim 64 , wherein the antisense oligonucleotide inhibits apoptosis-specific eIF-5A function, thereby inhibiting apoptosis. 
     
     
         68 . The method of  claim 64 , wherein the cell is comprised within an animal. 
     
     
         69 . The method of  claim 68 , wherein the antisense oligonucleotide is administered to the animal. 
     
     
         70 . An apoptosis inhibiting agent comprising an antisense oligonucleotide against the 3′-UTR of a mammalian nucleic acid molecule encoding apoptosis-specific eIF-5A, wherein the antisense oligonucleotide inhibits apoptosis-specific eIF-5A expression. 
     
     
         71 . The agent of  claim 70 , wherein the nucleic acid molecule comprises SEQ ID NO:3. 
     
     
         72 . The agent of  claim 70 , wherein the nucleic acid molecule consists of SEQ ID NO:3. 
     
     
         73 . A method of inhibiting apoptosis in a cell comprising administering to the cell an agent that inhibits the activity of deoxyhypusine synthase (DHS). 
     
     
         74 . The method of  claim 73 , wherein the agent is an oligonucleotide that is antisense to a mammalian nucleic acid molecule encoding apoptosis-specific DHS. 
     
     
         75 . The method of  claim 73 , wherein the agent is a ribozyme that inhibits the expression of endogenous mammalian apoptosis-specific DHS.

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