US2014213524A1PendingUtilityA1

Composition for regeneration of cartilage

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Assignee: IWASAKI NORIMASAPriority: Aug 23, 2011Filed: Aug 22, 2012Published: Jul 31, 2014
Est. expiryAug 23, 2031(~5.1 yrs left)· nominal 20-yr term from priority
Inventors:Norimasa IwasakiAtsushi SukegawaAkio MinamiNobuo Ohzawa
A61L 27/20A61L 2300/414A61L 2430/06A61L 27/54A61L 2300/252A61K 38/195A61K 31/734
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Claims

Abstract

A novel composition for regenerating a cartilage has been demanded, which can achieve a good effect of regenerating a hyaline cartilage that is a nearly normal cartilage without requiring the use of any transplanted cell. The present invention provides a composition for regenerating a cartilage, wherein (a) a monovalent metal salt of low endotoxin alginic acid and (b) SDF-1 are used in combination.

Claims

exact text as granted — not AI-modified
1 . A composition for cartilage regeneration wherein (a) a monovalent metal salt of a low endotoxin alginic acid and (b) SDF-1 are used in combination. 
     
     
         2 . The composition according to  claim 1 , wherein the composition does not contain a cell growth factor. 
     
     
         3 . The composition according to  claim 1 , wherein the SDF-1 is contained in the composition at a concentration of 0.2 μg/ml or higher and less than 100 μg/ml. 
     
     
         4 . The composition according to  claim 1 , wherein the composition is applied to a cartilage injury lesion, and is cured by applying a cross-linking agent to the surface of the composition. 
     
     
         5 . The composition according to  claim 4 , wherein the cross-linking agent is at least one metal ion compound selected from the group consisting of Ca 2+ , Mg 2+ , Ba 2+  and Sr 2+ . 
     
     
         6 . The composition according to  claim 1 , wherein the monovalent metal salt of alginic acid has a weight-average molecular weight of 500,000 or more in gel filtration chromatography. 
     
     
         7 . The composition according to  claim 1 , wherein viscosity of the composition is 400 mPa·s to 20,000 mPa·s. 
     
     
         8 . The composition according to any  claim 1 , wherein the composition does not contain cells for cartilage regeneration. 
     
     
         9 . The composition according to  claim 1 , wherein the composition does not contain a scaffold material for cells except (a) the monovalent metal salt of low endotoxin alginic acid. 
     
     
         10 . The composition according to  claim 1 , wherein the monovalent metal salt of alginic acid is potassium alginate or sodium alginate. 
     
     
         11 . The composition according to  claim 1 , wherein the monovalent metal salt of low endotoxin alginic acid has an endotoxin content of 100 EU/g or less. 
     
     
         12 . The composition according to  claim 1 , wherein the composition for cartilage regeneration is used for treating a cartilage injury lesion or for treating a cartilage disease.

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