Treatment and composition for wound healing

Abstract

A method and medicament for promoting wound healing in a subject is disclosed. The medicament comprises an effective amount of an agent comprising one or more of; (i) an activated protein C (APC), (ii) a functional fragment of an APC, (iii) an APC mimetic compound, and (iv) protein C. Delivery systems including gels, sponges, gauzes and meshes incorporating the agent for topical administration are also described.

1 .- 8 . (canceled) 
     
     
         9 . A method for promoting wound healing in a subject, said method comprising topically administering to said subject an effective amount of an agent comprising an activated protein C (APC), optionally in admixture with a pharmaceutically-acceptable carrier, wherein the wound is an eye wound and the topical administration of the agent promotes re-epithelialisation of the eye. 
     
     
         10 . The method of  claim 9 , wherein the agent is human APC. 
     
     
         11 . The method of  claim 9 , wherein the agent is administered to said subject within 1 to 10 hours of wounding. 
     
     
         12 . The method of  claim 9 , wherein the effective amount of the agent is in the range of 0.1 to 1000 μg per kg of body weight. 
     
     
         13 . The method of  claim 12 , wherein the effective amount of the agent is in the range of 0.1 to 10 μg per kg of body weight.