US2014221478A1PendingUtilityA1

Di-fluoro containing compounds as cysteine protease inhibitors

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Assignee: VIROBAY INCPriority: Oct 4, 2006Filed: Apr 7, 2014Published: Aug 7, 2014
Est. expiryOct 4, 2026(~0.2 yrs left)· nominal 20-yr term from priority
Inventors:John O. LinkCraig J. MossmanJie LiuSoon Hyung Woo
A61P 9/10A61P 37/00A61P 29/00A61P 25/00A61P 11/06C07C 255/46A61P 11/00A61P 17/06A61P 19/00C07C 2601/02A61K 31/26
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Claims

Abstract

The present invention is directed to compounds that are inhibitors of cysteine proteases, in particular, cathepsins B, K, L, F, and S, and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

Claims

exact text as granted — not AI-modified
1 .- 14 . (canceled) 
     
     
         15 . A compound having the following structure: 
       
         
           
           
               
               
           
         
         or a pharmaceutically acceptable salt thereof. 
       
     
     
         16 . A pharmaceutical composition comprising a compound of  claim 15  in admixture with one or more suitable excipients.

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