Preparation for Restenosis Prevention

Abstract

The invention relates to a preparation for restenosis prevention. The preparations for restenosis prevention known as yet do not reach sufficient active agent concentrations in the affected sections of the vascular walls as higher doses cause undesirable side effects. The present invention is a preparation to which at least one antihyperplastic agent is added that has a distribution ratio between butanol and water .gtoreq.0.5. The lipophilic active agent is absorbed by the vascular wall fast and in sufficient quantity. The preparation may be a liquid that can pass through capillaries and may contain a contrast agent so that the active agent is transferred into the vascular wall without any additional effort while the usually required contrast radiograms are taken. The preparation may also be applied to a catheter.

1 - 15 . (canceled) 
     
     
         16 . A catheter balloon comprising paclitaxel and a lipid coated thereon. 
     
     
         17 . The catheter balloon of  claim 16  wherein the paclitaxel and lipid are mixed together in a preparation. 
     
     
         18 . The catheter balloon of  claim 17  wherein the preparation further comprises a coagulation inhibitor. 
     
     
         19 . The catheter balloon of  claim 17  wherein the preparation further comprises a platelet aggregation inhibitor. 
     
     
         20 . The catheter balloon of  claim 17  wherein the preparation further comprises an enzyme inhibitor. 
     
     
         21 . The catheter balloon of  claim 17  wherein the preparation further comprises a calcium chelator. 
     
     
         22 . The catheter balloon of  claim 17  wherein the preparation further comprises an agent for enhancing artery/vein imaging. 
     
     
         23 . The catheter balloon of  claim 22  wherein the agent for enhancing artery/vein imaging is an X-ray contrast medium. 
     
     
         24 . The catheter balloon of  claim 17  wherein the preparation comprises a solubility promoter that does not form micelles. 
     
     
         25 . The catheter balloon of  claim 17  wherein the preparation is present in an amount effective for restenosis prevention. 
     
     
         26 . The catheter balloon of  claim 16  wherein the paclitaxel is present in an amount effective to irreversibly or reversibly bind to tissue at a minimum percentage of 10%. 
     
     
         27 . A method of treating vein or artery wall for preventing restensosis comprising local delivery of paclitaxel using the catheter balloon of  claim 16 .