Method and apparatus for predicting susceptibility to a developmental disorder

Abstract

A nucleotide sequence signal amplification composition that includes an isolated, synthetic nucleotide sequence of greater than 7 nucleotides. The sequence is a fragment of SEQ ID NO:3 and further comprising a T nucleotide at position 1438 of SEQ ID NO:3 and one or more primers that bind to the synthetic nucleotide sequence, a thermostable DNA polymerase, a restriction enzyme, or a combination thereof.

What is claimed is: 
     
         1 . A nucleotide sequence signal amplification composition comprising an isolated, synthetic nucleotide sequence of greater than 7 nucleotides comprising a fragment of SEQ ID NO:3 and further comprising a T nucleotide at position 1438 of SEQ ID NO:3 and one or more primers that bind to the synthetic nucleotide sequence, a thermostable DNA polymerase, a restriction enzyme, or a combination thereof. 
     
     
         2 . The nucleotide sequence signal amplification composition of  claim 1 , wherein the isolated, synthetic nucleotide sequence comprises SEQ ID NO:4 wherein X is a thymidine base (T). 
     
     
         3 . The nucleotide sequence signal amplification composition of  claim 1 , wherein the isolated, synthetic nucleotide sequence comprises-greater than 10 nucleotides. 
     
     
         4 . The nucleotide sequence signal amplification composition of  claim 1 , wherein the isolated synthetic nucleotide sequence comprises greater than 25 nucleotides. 
     
     
         5 . The nucleotide sequence signal amplification composition of  claim 1 , wherein the isolated synthetic nucleotide sequence of comprises greater than 60 nucleotides. 
     
     
         6 . The nucleotide sequence signal amplification composition of  claim 1 , wherein the isolated, synthetic nucleotide sequence is SEQ ID NO:4 wherein X is a thymidine base (T).