Antibody and antibody-containing composition

Abstract

For many diseases due to microbes or the like, proliferation of microbes themselves is a cause of a symptom. However, there were cases where a substance released by the microbes is a cause of a symptom. In such cases, when attempting to treat a disease with an antibody, it was necessary to obtain an antibody against an antigen that is a substance causing the disease. However, it was difficult to find the underlying substance causing the disease among substances released by the microbes. An antibody (polyclonal) binding to not only an antigen but also to a substance, which is secreted by the antigen and accelerates the deterioration of a symptom, is obtained by immunizing birds with a lysis solution produced from lysing microbial cells as an antigen. Further, an antibody obtained with a surface protein of a virus as an antigen is expected to inhibit an infection by a virus.

1 . A bird antibody against an antigen that is a lysis solution of a microbial cell. 
     
     
         2 . The antibody according to  claim 1 , wherein the antibody is IgY obtained from an egg of a bird immunized with the lysis solution of the microbial cell as an antigen. 
     
     
         3 . The antibody according to  claim 1 , wherein the bird is an ostrich. 
     
     
         4 . The antibody according to  claim 1 , wherein the microbial cell is  Staphylococcus aureus.    
     
     
         5 . The antibody according to  claim 1 , wherein the microbial cell is  Propionibacterium acnes.    
     
     
         6 . A bird antibody against an antigen that is a surface protein of a virus. 
     
     
         7 . The antibody according to  claim 6 , wherein the antibody is IgY obtained from an egg of a bird immunized with the protein as an antigen. 
     
     
         8 . The antibody according to  claim 7 , wherein the bird is an ostrich. 
     
     
         9 . The antibody according to any one of  claims 6 - 8 , wherein the protein comprises Human Immunodeficiency Virus (HIV) gp120. 
     
     
         10 . The antibody according to any one of  claims 6 - 8 , wherein the protein comprises any one of Human Papilloma Virus (HPV) type 6, 11, 16, or 18. 
     
     
         11 - 12 . (canceled) 
     
     
         13 . A method of treating skin of a subject, comprising administering the antibody according to  claim 1  to the subject. 
     
     
         14 . The method of  claim 13 , wherein the subject has atopy. 
     
     
         15 . The method of  claim 13 , wherein the subject has acne. 
     
     
         16 . A method of preventing or treating virus infection of a subject, comprising administering the antibody according to  claim 9  to the subject. 
     
     
         17 . The method of  claim 16 , wherein the virus is HIV. 
     
     
         18 . The method of  claim 16 , wherein the virus is HPV.