US2014243402A1PendingUtilityA1

Artemisinins in the Clinical and Veterinary Management of Kinetoplastid Infextions

55
Individually held — no corporate assignee on recordPriority: Dec 21, 2006Filed: Feb 4, 2014Published: Aug 28, 2014
Est. expiryDec 21, 2026(~0.4 yrs left)· nominal 20-yr term from priority
Inventors:Bruno K. KubataSamuel K. MartinWilbur K. Milhous
A61K 36/282A61P 33/00A61P 31/00A61K 31/366A61K 31/357
55
PatentIndex Score
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Cited by
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References
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Claims

Abstract

The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua . The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.

Claims

exact text as granted — not AI-modified
1 . A method of treating kinetoplastid infections comprising:
 (a) diagnosing a kinetoplastid infection in a mammal; and   (b) administering to said mammal a pharmaceutical composition wherein said composition contains a pharmaceutical dose of artemisinin or dihdro artemisinin sufficient to decrease said kinetoplastid infection.   
     
     
         2 . (canceled) 
     
     
         3 . (canceled) 
     
     
         4 . (canceled) 
     
     
         5 . The method of  claim 1 , wherein said administering is via an oral route or intraperitoneally. 
     
     
         6 . The method of  claim 1 , wherein said dose is 4-8 ul/kg. 
     
     
         7 . The method of  claim 1 , wherein said kinetoplastid infections are selected from Leishmania infection and trypanosome infection. 
     
     
         8 . (canceled) 
     
     
         9 . A method of inhibiting the growth of kinetoplastid organisms comprising: administering an effective amount of artemisinin or dihydro artemisinin to said organisms. 
     
     
         10 . (canceled) 
     
     
         11 . A method of treating kinetoplastid infections, comprising
 (a) diagnosing a kinetoplastic infection in a mammal;   (b) administering to said mammal a pharmaceutical dose of artemisinin or, dihydro artemisinin.   
     
     
         12 . The method of  claim 11 , wherein said dose is 4-8 ul/Kg. 
     
     
         13 . The method of  claim 11 , wherein said mammal is a human. 
     
     
         14 . (canceled) 
     
     
         15 . (canceled)

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