Composition comprising an onion extract and liposomes

Abstract

The present invention relates to a composition comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes. Furthermore the present invention relates to a method for preparing a composition comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes. Further, the present invention relates to a composition comprising an onion extract (A) ( Allium cepa ) and liposomes, obtainable by or obtained by said method. Furthermore, the present invention relates to compositions comprising a first onion extract (A), and liposomes, wherein at least a portion of the onion extract is encapsulated in the liposomes, for use in treating and/or preventing scars.

1 - 26 . (canceled) 
     
     
         27 . A composition comprising
 a first onion extract (A), and liposomes,   wherein at least a portion of the first onion extract (A) is encapsulated in the liposomes.   
     
     
         28 . The composition according to  claim 27 , wherein the liposomes are phospholipid comprising liposomes. 
     
     
         29 . The composition according to  claim 28 , wherein the liposomes are lecithin comprising liposomes. 
     
     
         30 . The composition according to  claim 27 , wherein the liposomes have a diameter in the range of from 50 to 450 nm, measured with Photon Correlation Spectroscopy 
     
     
         31 . The composition according to  claim 27 , comprising the first onion extract (A) in an amount in the range of from 0.1-25 weight % based on the total weight of the composition. 
     
     
         32 . The composition according to  claim 27 , wherein the first onion extract (A) comprises a solvent S 2 , said solvent comprising at least one alcohol and water. 
     
     
         33 . The composition according to  claim 32 , wherein the solvent comprises ethanol and water. 
     
     
         34 . The composition according to  claim 27 , wherein the first onion extract (A) is an  Allium Cepa  extract. 
     
     
         35 . The composition according to  claim 27 , wherein the composition further comprises one or more or more active agents and/or one or more cosmetically and/or pharmaceutically acceptable carrier or excipients. 
     
     
         36 . The composition according to  claim 27 , wherein the composition is a cream, an ointment, a gel or an emulsion. 
     
     
         37 . The composition according to  claim 36 , wherein the composition is a gel or an emulsion. 
     
     
         38 . The composition according to  claim 28 , wherein the composition is a cream, an ointment, a gel or an emulsion. 
     
     
         39 . The composition according to  claim 38 , wherein the composition is a gel or an emulsion. 
     
     
         40 . The composition according to  claim 27 , wherein the composition additionally comprises at least one compound selected from the group consisting of PEG, Panthenol and hyaluronic acid. 
     
     
         41 . A method for preparing a composition comprising
 a first onion extract (A), and liposomes,   wherein at least a portion of the first onion extract is encapsulated in the liposomes, the method comprising:   (i) providing a first onion extract (A)   (ii) providing liposomes or membrane components capable of forming liposomes upon contact with the onion extract (A), and   (iii) contacting the first onion extract (A) according to (i) with the liposomes or the membrane components capable of forming liposomes upon contact with the onion extract (A) according to (ii), thereby encapsulating at least a portion of the first onion extract (A) into liposomes.   
     
     
         42 . The method according to  claim 41 , further comprising
 (iv) providing a composition (C1) comprising one or more cosmetically and/or pharmaceutically acceptable carriers or excipients   (v) mixing (C1) with the composition according to (iii).   
     
     
         43 . The method according to  claim 41 , wherein step (i) comprises
 (a) extracting fresh or dried onions, preferably  Allium cepa , with a solvent S 1  comprising at least one alcohol to give a liquid phase L 1  and a solid residue R o      (b) separating the liquid phase L 1  from the solid residue R o      (c) evaporating the liquid phase L 1  to give a residue R 1      (d A ) redissolving the residue R 1  in a solvent S 2  comprising at least one alcohol and water to give the first onion extract (A)   wherein the first onion extract (A) comprises R 1  in an amount in an amount of 20 to 33% by weight, or 25-30% by weight, based on the total weight of the first onion extract (A).   
     
     
         44 . A method for treating and/or preventing a scar in a subject in need thereof, comprising administration of an effective amount of a composition according to  claim 27 . 
     
     
         45 . The method according to  claim 44 , wherein the method comprises improving the appearance of scar tissue and/or for reduction of scar tissue. 
     
     
         46 . The method according to  claim 44 , wherein the method comprises softening the scar tissue or reducing discoloration of the scar. 
     
     
         47 . The method according to  claim 44 , wherein the method further prevents excessive fibroblast proliferation. 
     
     
         48 . The method according to  claim 44 , wherein the composition is administered once a day.