US2014249226A1PendingUtilityA1

Methods of administering compositions comprising docosapentaenoic acid

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Assignee: MATINAS BIOPHARMA INCPriority: Jun 17, 2012Filed: May 15, 2014Published: Sep 4, 2014
Est. expiryJun 17, 2032(~5.9 yrs left)· nominal 20-yr term from priority
Inventors:George BobotasAbdel Fawzy
A61K 9/4858A61K 31/40A61K 31/202A61K 9/4825A61P 9/00A61P 3/06A61K 31/232A61K 31/201
71
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Claims

Abstract

The present invention relates to compositions comprising docosapentaenoic acid and methods of reducing lipid parameters, such as triglycerides, total cholesterol, low density lipoprotein (LDL) cholesterol, non-HDL cholesterol, free fatty acids, and other lipids, comprising administration of omega-3 docosapentaenoic acid.

Claims

exact text as granted — not AI-modified
1 - 22 . (canceled) 
     
     
         23 . A method of reducing a lipid parameter level in a subject from a baseline lipid parameter level, wherein the lipid parameter is selected from the group consisting of: total cholesterol, VLDL-cholesterol, apolipoprotein B (apo B), and apolipoprotein C-III (apo C-III), comprising administering to the subject a composition comprising a daily dosage of docosapentaeoic acid (DPA) of about 120 mg/day to about 150 mg/day. 
     
     
         24 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 150 mg/day to about 200 mg/day. 
     
     
         25 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 200 mg/day to about 250 mg/day. 
     
     
         26 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 250 mg/day to about 300 mg/day. 
     
     
         27 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 300 mg/day to about 400 mg/day. 
     
     
         28 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 400 mg/day to about 600 mg/day. 
     
     
         29 . The method of  claim 23 , wherein the composition comprises a daily dosage of DPA of about 600 mg/day to about 1000 mg/day. 
     
     
         30 . The method of  claim 23 , wherein the composition further comprises eicosapentaenoic acid (EPA) and, wherein the amount of EPA and DPA is about 55% or more by weight of the total amount of fatty acids, and wherein the ratio of DHA:DPA is no more than 1:1. 
     
     
         31 . The method of  claim 23 , wherein the amount of EPA and DPA is selected from the group consisting of: about 60% or more, about 65% or more, about 70% or more, about 75% or more, about 80% or more, about 85% or more, and about 90% or more by weight of the total amount of fatty acids. 
     
     
         32 . The method of  claim 23 , wherein the composition comprises further omega-6 fatty acids in an amount of no more than 6% of total amount of fatty acids. 
     
     
         33 . The method of  claim 23 , wherein the composition comprises no more than about 30% docosahexaenoic acid (DHA) by weight of fatty acids present in the composition. 
     
     
         34 . The method of  claim 23 , wherein the composition comprises no more than about 10% docosahexaenoic acid (DHA) by weight of fatty acids present in the composition. 
     
     
         35 . The method of  claim 23 , wherein the composition comprises no more than about 5% docosahexaenoic acid (DHA) by weight of fatty acids present in the composition. 
     
     
         36 . The method of  claim 23 , wherein the composition comprises DPA in ethyl ester form. 
     
     
         37 . The method of  claim 23 , wherein the composition comprises DPA in free fatty acid form. 
     
     
         38 . The method of  claim 23 , wherein the composition further comprises docosahexaenoic acid (DHA), and the ratio of DHA:DPA is no more than 2:1. 
     
     
         39 . The method of  claim 23 , wherein the composition further comprises docosahexaenoic acid (DHA), and the ratio of DHA:DPA is no more than 1:1. 
     
     
         40 . The method of  claim 23 , wherein the composition further comprises docosahexaenoic acid (DHA), and the ratio of DHA:DPA is no more than 1:2. 
     
     
         41 . The method of  claim 23 , wherein the composition further comprises docosahexaenoic acid (DHA), and the ratio of DHA:DPA is no more than 1:4. 
     
     
         42 . The method of  claim 23 , wherein the composition comprises at least about 6% docosapentaenoic acid (DPA) by weight of fatty acids present in the composition. 
     
     
         43 . The method of  claim 23 , wherein the composition comprises at least about 20% docosapentaenoic acid (DPA) by weight of fatty acids present in the composition. 
     
     
         44 . The method of  claim 23 , wherein the composition comprises at least about 50% docosapentaenoic acid (DPA) by weight of fatty acids present in the composition.

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