Multi-CBV Vaccine for Preventing or Treating Type I Diabetes

Abstract

The invention is directed to a vaccine comprising: i) coxsackie B virus CBV1 and CBV2, and ii) at least one coxsackie B virus selected from CBV3, CBV4, CBV5 and CBV6. The CBVs are present in the vaccine in inactivated form, in the form of a component of the virus or as an antibody against the virus. The vaccine is effective in preventing and treating type 1 diabetes. So is an anti-coxsackie B virus composition provided.

1 . A method for preventing or treating type 1 diabetes in a subject in need thereof comprising administering to the subject a vaccine comprising:
 i) coxsackie B virus CBV1 and CBV2 in inactivated form or in the form of a component of said virus, and
 at least one coxsackie B virus selected from the group consisting of CBV3, CBV4, CBV5 and CBV6 in inactivated form or in the form of a component of said virus 
   for use in preventing or treating type 1 diabetes.   
     
     
         2 . The method according to  claim 1 , wherein the vaccine comprises CBV1, CBV2, CBV3, CBV4, CBV5 and CBV6. 
     
     
         3 . The method according to  claim 1  or  2 , wherein the CBVs are inactivated. 
     
     
         4 . The method according to  claim 1  or  2 , wherein the component is a subunit of the CBV. 
     
     
         5 . The method according to  claim 1  or  2 , wherein the component is a virus-like particle (VLP) of the CBV. 
     
     
         6 . The method according to  claim 1  or  2 , wherein the component is a nucleic acid of the CBV. 
     
     
         7 . The method according to  claim 1  or  2 , wherein the vaccine further comprises a pharmaceutically acceptable excipient and adjuvant. 
     
     
         8 . A method for preventing or treating type 1 diabetes in a subject in need thereof comprising administering to the subject a vaccine comprising:
 i) antibodies against coxsackie B virus CBV1 and CBV2, and
 antibodies against at least one coxsackie B virus selected from the group consisting of CBV3, CBV4, CBV5 and CBV6 
   for use in.   
     
     
         9 . The method according to  claim 8 , comprising antibodies against CBV1, CBV2, CBV3, CBV4, CBV5 and CBV6. 
     
     
         10 . The method according to  claim 9  or  10 , wherein the vaccine is to be administered to a pregnant woman, and optionally postnatally to her baby. 
     
     
         11 . The method according to  claim 9 , wherein the use comprises passive immunization by administering antibodies to the CBVs. 
     
     
         12 . (canceled) 
     
     
         13 . (canceled) 
     
     
         14 . (canceled) 
     
     
         15 . A method for preventing or treating type 1 diabetes in a subject in need thereof comprising administering to the subject an anti-coxsackie B virus composition. 
     
     
         16 . The method according to  claim 1  or  2 , wherein the vaccine is to be administered to a pregnant woman, and optionally postnatally to her baby.