US2014255507A9PendingUtilityA9

Method for promoting the synthesis of collagen and proteoglycan in chondrocytes

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Assignee: MASUDA KOICHIPriority: Oct 14, 2010Filed: Oct 11, 2011Published: Sep 11, 2014
Est. expiryOct 14, 2030(~4.3 yrs left)· nominal 20-yr term from priority
Inventors:Koichi MasudaMitsuru Naiki
A61P 43/00A61P 9/00A61P 29/00A61P 25/04A61P 19/00A61K 35/76A61K 35/36G01N 2333/07A61P 19/08G01N 33/5082C12Q 1/025A61K 35/12A61K 35/32C12N 5/0652
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Claims

Abstract

The synthesis of collagen and proteoglycan in chondrocytes, such as intervertebral disc cells, articular chondrocytes and meniscal cells is promoted by administration of an extract from inflamed tissue inoculated with vaccinia virus.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 . A method for promoting the synthesis of proteoglycan and/or collagen in chondrocytes comprising administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         2 . A method as claimed in  claim 1  wherein said chondrocytes comprise intervertebral disc cells. 
     
     
         3 . A method as claimed in  claim 2  wherein said intervertebral disc cells comprise bovine nucleus pulposus cells and/or anulus fibrosus cells. 
     
     
         4 . A method as claimed in  claim 2  wherein proteoglycan synthesis is promoted. 
     
     
         5 . A method as claimed in  claim 2  wherein collagen synthesis is promoted. 
     
     
         6 . A method as claimed in  claim 2  wherein the inflamed tissue is a rabbit skin tissue. 
     
     
         7 . A method as claimed in  claim 4  wherein said intervertebral disc cells comprise bovine nucleus pulposus cells. 
     
     
         8 . A method as claimed in  claim 4  wherein said intervertebral disc cells comprise anulus fibrosus cells. 
     
     
         9 . A method as claimed in  claim 5  wherein said intervertebral disc cells comprise bovine nucleus pulposus cells. 
     
     
         10 . A method as claimed in  claim 5  wherein said intervertebral disc cells comprise anulus fibrosus cells. 
     
     
         11 . A method for determining or evaluating an extract isolated from inflamed tissue inoculated with vaccinia virus comprising measuring a promoting activity on the synthesis of proteoglycan and/or collagen in cultured chondrocytes by said extract as an index. 
     
     
         12 . A method as claimed in  claim 11  wherein said chondrocytes comprise intervertebral disc cells. 
     
     
         13 . A method as claimed in  claim 12  wherein said intervertebral disc cells comprise bovine nucleus pulposus cells and/or anulus fibrosus cells. 
     
     
         14 . A method as claimed in  claim 12  wherein proteoglycan synthesis is promoted. 
     
     
         15 . A method as claimed in  claim 12  wherein collagen synthesis is promoted. 
     
     
         16 . A method as claimed in  claim 12  wherein the inflamed tissue is a rabbit skin tissue. 
     
     
         17 . A method for regenerating a chondrocyte extracellular matrix, comprising administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         18 . A method as claimed in  claim 17  wherein the chondrocyte extracellular matrix is an intervertebral disc cell extracellular matrix. 
     
     
         19 . A method for determining or evaluating an extract isolated from inflamed tissue inoculated with vaccinia virus comprising measuring a regenerating activity of a chondrocyte extracellular matrix by said extract as an index. 
     
     
         20 . A method as claimed in  claim 19  wherein said chondrocyte extracellular matrix is an intervertebral disc cell extracellular matrix. 
     
     
         21 . A method for treating degenerative intervertebral discs, comprising administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         22 . A method for treating pain caused by intervertebral disc degeneration, comprising regenerating an intervertebral disc cell extracellular matrix by administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         23 . A method for treating a pain caused by intervertebral disc degeneration comprising promoting the synthesis of proteoglycan in intervertebral disc cells by administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         24 . A method for treating pain caused by intervertebral disc degeneration, comprising promoting the synthesis of collagen in intervertebral disc cells by administering to a patient in need of such treatment an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         25 . An agent for treating or preventing degenerative intervertebral discs comprising an extract isolated from inflamed tissue inoculated with vaccinia virus. 
     
     
         26 . An agent for promoting the synthesis of proteoglycan and/or collagen in intervertebral disc cells comprising an extract isolated from inflamed tissue inoculated with vaccinia virus.

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