Immunogenic lhrh compositions and methods relating thereto

Abstract

The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

1 . A vaccine composition comprising an LHRH-diphtheria toxoid conjugate and an ionic polysaccharide, wherein the amino acid sequence of said LHRH is selected from the group consisting of SEQ ID NO: 1, SE Q ID NO: 2, SEQ ID NO7 3 and SEC) ID NO: 4. 
     
     
         2 . The vaccine composition according to  claim 1 , wherein said ionic polysaccharide is DEAE-dextran. 
     
     
         3 . The vaccine composition according to  claim 1 , wherein the carboxy terminus of said amino acid sequence is amidated. 
     
     
         4 . The vaccine composition according to  claim 1 , wherein the amino acid sequence of said LHRH is SEQ ID NO:1. 
     
     
         5 . The vaccine composition according to  claim 1 , wherein the amino acid sequence of said LHRH is SEQ ID NO:3. 
     
     
         6 . A method of achieving production gains in pigs, said method comprising administering to said pigs an effective amount of the composition of  claim 1 . 
     
     
         7 . The method according to  claim 6  wherein said production gain is the reduction or elimination of unwanted organoleptic characteristics from the meat of said pigs. 
     
     
         8 . A method, of reducing or eliminating unwanted organoleptic characteristics from the meat of a male pig, said method comprising administering to said pig an effective amount of a vaccine composition according to  claim 1 .