Biocompatible fiber textiles for implantation

Abstract

A biocompatible textile and methods for its use and fabrication are disclosed. The textile may be fabricated from electrospun fibers forming windings on a mandrel, in which the windings form openings having a mesh size between adjacent windings. The textile may also be fabricated by the addition of solvent-soluble particles incorporated into the textile while the windings are formed. Such particles may be removed by exposing the textile to a solvent, thereby dissolving them. Disclosed are also replacements for animal organs composed of material including at least one layer of an electrospun fiber textile having a mesh size. Such replacements for animal organs may include biocompatible textiles treated with a surface treatment process.

1 . A biocompatible textile comprising:
 at least one electrospun fiber, comprising at least one polymer, disposed on a mandrel,   wherein:   the electrospun fiber forms a plurality of windings on the mandrel,   each winding of the plurality of windings forms an opening with an adjacent winding, thereby forming a plurality of openings between a plurality of adjacent windings, and   the plurality of openings comprises a mesh size.   
     
     
         2 . The biocompatible textile of  claim 1 , wherein the textile is bio-stable. 
     
     
         3 . The biocompatible textile of  claim 1 , wherein the textile is bio-absorbable or bio-degradable. 
     
     
         4 .- 5 . (canceled) 
     
     
         6 . The biocompatible textile of  claim 1 , wherein the electrospun fiber is selected from one or more of electrospun polyethylene terephthalate, electrospun polyester, electrospun polymethylmethacrylate, electrospun polyacrylonitrile, electrospun silicone, electrospun polyurethane, electrospun polycarbonate, electrospun polyether ketone ketone, electrospun polyether ether ketone, electrospun polyether imide, electrospun polyamide, electrospun polystyrene, electrospun polyether sulfone, electrospun polysulfone, electrospun polycaprolactone (PCL), electrospun polylactic acid (PLA), electrospun polyglycolic acid (PGA), electrospun polyglycerol sebacic, electrospun polydiol citrate, electrospun polyhydroxy butyrate, electrospun polyether amide, electrospun polydiaxanone, electrospun chitosan, and combinations or derivatives thereof. 
     
     
         7 . The biocompatible textile of  claim 1 , wherein the at least one electrospun fiber comprises a plurality of electrospun fibers. 
     
     
         8 . The biocompatible textile of  claim 1 , wherein the at least one electrospun fiber comprises an at least one surface-treated electrospun fiber. 
     
     
         9 . The biocompatible textile of  claim 8 , wherein the at least one surface-treated electrospun fiber comprises an at least one electrospun fiber comprising a plurality of particles in physical communication with at least a portion of the surface of the electrospun fiber. 
     
     
         10 . The biocompatible textile of  claim 9 , wherein the plurality of particles has an average particle size of about 5 μm to about 300 μm. 
     
     
         11 . (canceled) 
     
     
         12 . The biocompatible textile of  claim 9 , wherein the plurality of particles comprises a salt, a sugar, a hydrogel material, or any combination thereof. 
     
     
         13 . The biocompatible textile of  claim 1 , wherein the plurality of windings forms a plurality of circumferential layers. 
     
     
         14 . The biocompatible textile of  claim 13 , wherein at least two of the plurality of circumferential layers have at least one point of mutual attachment defined by a tack weld. 
     
     
         15 . The biocompatible textile of  claim 13 , wherein at least one of the plurality of circumferential layers comprises sintered windings of the at least one electrospun fiber. 
     
     
         16 . The biocompatible textile of  claim 13 , wherein at least one of the plurality of circumferential layers is in physical contact with a plurality of water soluble particles. 
     
     
         17 . The biocompatible textile of  claim 13 , wherein at least one of the plurality of circumferential layers has a mesh size determined by a spacing of about 2 micrometers to about 50 micrometers between adjacent windings of the at least one electrospun fiber. 
     
     
         18 .- 27 . (canceled) 
     
     
         28 . The biocompatible textile of  claim 1 , wherein at least one surface of the biocompatible textile comprises windings of the at least one electrospun fiber treated with a surface treatment. 
     
     
         29 . The biocompatible textile of  claim 1 , wherein at least one surface of the biocompatible textile comprises windings of the at least one electrospun fiber exposed to a jet of pressurized air, a jet of pressurized ionized air, gamma radiation, and a solvent. 
     
     
         30 . The biocompatible textile of  claim 1 , wherein at least one surface of the biocompatible textile comprises windings of the at least one electrospun fiber exposed to one or more of water and an alcohol. 
     
     
         31 . The biocompatible textile of  claim 1 , wherein the biocompatible textile comprises windings of the at least one electrospun fiber sonicated in water, alcohol, or a combination thereof. 
     
     
         32 . The biocompatible textile of  claim 1 , wherein at least one surface of the biocompatible textile comprises windings of the at least one electrospun fiber exposed to a gas plasma discharge. 
     
     
         33 . The biocompatible textile of  claim 32 , wherein the gas is one or more of air and carbon tetrafluoride. 
     
     
         34 . The biocompatible textile of  claim 1 , wherein the mandrel has a cylindrical shape, a biological organ-shape, a shape determined by a computer model, or a shape based on a biological organ of a patient. 
     
     
         35 .- 37 . (canceled) 
     
     
         38 . The biocompatible textile of  claim 1 , wherein the mandrel is a collapsible mandrel. 
     
     
         39 . The biocompatible textile of  claim 1 , wherein the mandrel has a non-stick surface comprising a polytetrafluoroethylene, a stainless steel, an aluminum, or combination thereof. 
     
     
         40 . (canceled) 
     
     
         41 . A biocompatible textile comprising:
 an at least one electrospun fiber, comprising at least one polymer, disposed longitudinally along a linear axis of a mandrel, thereby forming a plurality of textile threads, wherein:   the at least one electrospun fiber forms openings between adjacent linearly deposited textile threads of a mesh size; and   the plurality of openings comprises a mesh size.   
     
     
         42 . A method for fabricating a biocompatible textile comprising:
 electrospinning a biocompatible polymer into an electrospun fiber;   contacting the electrospun fiber with a particulate material having a solubility in a solvent;   contacting the electrospun fiber with a receiving surface, thereby forming a polymer network thereon comprising a plurality of electrospun fiber threads and a plurality of spaces between adjacent electrospun fiber threads;   removing the polymer network from the receiving surface, thereby forming a biocompatible textile; and   contacting the biocompatible textile with the solvent thereby removing the particulate material,   wherein the plurality of openings comprises a mesh size.   
     
     
         43 . The method of  claim 42 , wherein the solvent is water. 
     
     
         44 . The method of  claim 42 , wherein the particulate material is a salt, a sugar, a hydrogel, or any combination thereof. 
     
     
         45 .- 47 . (canceled)