Compound, extract isolated from antrodia camphorate, and method of inhibiting cancer cell growth

Abstract

Disclosed is a compound isolated from Antrodia camphorata , represented by formula I: wherein R1 is a hydrogen atom or an acetyl group; and a method of inhibiting cancer cell growth by using the compound, the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.

What is claimed is: 
     
         1 . A compound isolated from  Antrodia camphorata , represented by formula I: 
       
         
           
           
               
               
           
         
       
       wherein R1 is a hydrogen atom or an acetyl group. 
     
     
         2 . The compound as claimed in  claim 1 , wherein R1 is a hydrogen atom, and the compound is represented by formula II: 
       
         
           
           
               
               
           
         
       
     
     
         3 . The compound as claimed in  claim 1 , wherein R1 is an acetyl group, and the compound is represented by formula III: 
       
         
           
           
               
               
           
         
       
     
     
         4 . A method of inhibiting cancer cell growth by using the compound as claimed in  claim 1 , wherein the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer. 
     
     
         5 . An extract of  Antrodia camphorate  for inhibiting cancer cell growth, extracted by the following steps: extracting a fruiting body, mycelium, or the mixture thereof twice, with an ethanol solution with a ratio of 1:10 to obtain two ethanol extracts, concentrating the ethanol extracts to yield a crude extract, the crude extract being extracted three times with dichloromethane/water (1:1) to form a dichloromethane layer and a water layer, the dichloromethane layer being loaded to a layered silica gel column with hexane/dichloromethane (1:4), dichloromethane, and methanol/dichloromethane (5:95) to yield the extract. 
     
     
         6 . The extract of  Antrodia camphorate  for inhibiting cancer cell growth as claimed in  claim 5 , wherein the cancer is selected from the group consisting of lung cancer, colon cancer, prostate cancer, liver cancer and breast cancer.