US2014287494A1PendingUtilityA1
Mesendoderm and mesoderm cell populations
Assignee: ICAHN SCHOOL MED MOUNT SINAIPriority: May 17, 2002Filed: Dec 17, 2013Published: Sep 25, 2014
Est. expiryMay 17, 2022(expired)· nominal 20-yr term from priority
A61P 43/00A61P 9/00A61P 9/04A61P 3/10A61P 7/06A61P 35/02A61P 21/04A61P 17/00A61P 19/00A61P 1/16G01N 33/5073C12N 2500/90C12N 2501/415C12N 5/0606C12N 2506/02C12N 5/0603C12N 2501/16
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Abstract
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
Claims
exact text as granted — not AI-modified1 - 30 . (canceled)
31 . An isolated mammalian cell population enriched for brachyury + and KDR/Flk-1 + precardiac mesoderm cells derived from brachyury + and KDR/Flk-1 − cells wherein the KDR/Flk-1 + cells are capable of becoming cells of a cardiomyocyte lineage.
32 . An isolated mammalian cell population enriched for brachyury + and KDR/Flk-1 − pre-hemangioblast mesoderm cells wherein the cells are capable of becoming cells of a vascular smooth muscle lineage, an endothelial cell lineage, and a hematopoietic cell lineage, and are not capable of becoming cells of endodermal or ectodermal lineages.Cited by (0)
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