Composition for tipical use for treating skin disorders

Abstract

It is described a composition, topically administrable, comprising as active ingredients L-carnitine or a derivative thereof, biotin, and at least one or more of the following active ingredients: vitamin B 12; vitamin E; bisabolol; and panthenol; useful for treating skin disorders.

1 . Composition, for topical use, comprising as active ingredients L-carnitine and/or one or more alkanoyl L-carnitines, or mixture thereof, or one of their pharmaceutically acceptable salts; biotin; and one ore more of the following active ingredients: vitamin B 12, vitamin E, bisabolol and panthenol. 
     
     
         2 . Composition of  claim 1 , comprising as active ingredients L-carnitine; biotin; vitamin E; bisabolol; and panthenol. 
     
     
         3 . Composition of  claim 1 , comprising as active ingredients L-carnitine; Biotin and vitamin B 12. 
     
     
         4 . Composition of  claim 1 , wherein:
 L-carnitine or a derivative thereof is present in an amount of from 0.1 to 20% by weight; or a derivative thereof is present in an amount of from   0.01 to 20% by weight;   vitamin B 12 or a derivative thereof is present in an amount of from 0.001 to 10% by weight;   vitamin E or a derivative thereof is present in an amount of from 0.01 to 10% by weight;   bisabolol or a derivative thereof is present in an amount of from 0.01 to 20% by weight; and   panthenol or a derivative thereof is present in an amount of from 0.01 to 20% by weight.   
     
     
         5 - 6 . (canceled) 
     
     
         7 . Method of preventing and/or treating inflammatory and/or degenerative disturbances of the skin with the composition of  claim 1  in patients in need thereof comprising
 administering to said patients an effective amount of the composition of  claim 1  and 
 treating said patients of said inflammatory and/or degenerative disturbances of the skin. 
 
     
     
         8 . Composition of  claim 7 , in which the disturbance of the skin is selected from the group consisting of: erythematous, inflammatory, allergic, autoimmune and oxidative disturbance of the skin. 
     
     
         9 . Composition of  claim 7 , in which the disturbance of the skin is selected from the group consisting of: dermatitis or dermatoses. 
     
     
         10 . Composition of  claim 1 , further comprising coenzymes, antioxidants, vitamins, mineral salts and solar filter. 
     
     
         11 . Composition of  claim 1 , in the form of ointments, creams, lotions baths, solutions powders, gels, or in liposome form. 
     
     
         12 . Composition of  claim 1 , in which the pharmaceutically acceptable salt of L-carnitine or alkanoyl L-carnitine is selected from the group consisting of: chloride, bromide, orotate, aspartate, acid aspartate, acid citrate, magnesium citrate, phosphate, acid phosphate, fumarate and acid fumarate, magnesium fumarate, lactate, maleate and acid maleate, oxalate, acid oxalate, pamoate, acid pamoate, sulphate, acid sulphate, glucose phosphate, tartrate and acid tartrate, glycerophosphate, mucate, magnesium tartrate, 2-amino-ethanesulphonate, magnesium 2-amino-ethanesulphonate, methanesulphonate, choline tartrate, trichloroacetate, and trifluoroacetate.