Medicament for the treatment of fungal infections particularly aspergillosis

Abstract

The combination of pentraxin PTX3 with antifungals is described for the treatment of fungal infections and particularly for infections caused by Aspergillus fumigatus.

1 . Combination of pentraxin PTX3 and an antifungal agent. 
     
     
         2 . Combination according to  claim 1 , wherein the antifungal agent is amphotericin B. 
     
     
         3 . Combination according to  claim 2 , wherein the amphotericin B is in deoxycholate form or in a liposomal formulation. 
     
     
         4 . A pharmaceutical composition comprising the combination according to  claim 1 . 
     
     
         5 . The composition of  claim 4  comprising a suboptimal dose of the antifungal agent. 
     
     
         6 . A method for the therapeutic treatment of fungal infections, comprising administering an effective dose of a medicament comprising the pharmaceutical composition of  claim 4  to a subject in need thereof. 
     
     
         7 . The method of  claim 6 , wherein said medicament comprises a suboptimal dose of the antifungal agent. 
     
     
         8 . The method according to  claim 6 , wherein the fungal infection is pulmonary aspergillosis. 
     
     
         9 . A method for the therapeutic treatment of pulmonary aspergillosis, comprising administering an effective dose of pentraxin PTX3 and an antifungal agent to a subject in need thereof.