4r,5s-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with nootropic activity

Abstract

The invention relates to the 5S,4R-enantiomer of 2-(5-methyl-2-oxo-4-phenyl-pyrrolidin-1-yl)-acetamide with cognition enhancing activity of high pharmacological value and to its preparation method which includes the synthesis of 5S-methyl-4R-phenylpyrrolidin-2-one, its N-alkylation with ethyl haloacetate and the treatment of intermediate ethyl 2-(5S-methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetate with ammonia.

1 . 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide of Formula I 
       
         
           
           
               
               
           
         
       
     
     
         2 . A method of treating a condition requiring a nootropic agent in a subject in need thereof, comprising administration of an effective amount of the 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide of  claim 1 . 
     
     
         3 . A method of enhancing cognition in a subject in need thereof, comprising administration of an effective amount of the 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide of  claim 1 . 
     
     
         4 . A method of treating cognitive deficits in a subject in need thereof, comprising administration of an effective amount of the 2-(5S-Methyl-2-oxo-4R-phenyl-pyrrolidin-1-yl)-acetamide of  claim 1 .