Systems and methods for calculating patient dosage

Abstract

Systems and methods for providing a dosage on a device comprising an electronic circuit, an input device, and a display screen. The method includes receiving an input signal of a user indicating an input directed to a patient sex and patient status selected from the group comprising new patient, returning patient and booster patient. If the patient sex is female, an effective estradiol dosage and an effective testosterone dosage are determined using dosage calculation methods selected based on the patient status and additional female input parameters. If the patient sex is male an effective testosterone dosage is determined using dosage calculation methods selected based on the patient status and additional male input parameters.

We claim: 
     
         1 . A system for of determining a dosage of a hormone to be administered to a patient, the system comprising:
 an input device;   a display screen; and   at least one electronic circuit configured to carry out the steps of:
 receiving an input signal from the input device related to a patient sex and a patient status; 
 selecting dosage calculation methods to apply to the input signal, the dosage calculation methods selected based on at least one of the patient sex, the patient status, and additional input parameters; 
 calculating, using the electronic circuit, at least one of an effective estradiol dosage and an effective testosterone dosage based on the selected dosage calculation methods; and 
 displaying, on the display screen, the calculated effective dosages. 
   
     
     
         2 . The system according to  claim 1 , wherein the patient status is selected from a group comprising new patient, returning patient and booster patient. 
     
     
         3 . The system according to  claim 2 , wherein the electronic circuit is further configured to carry out the steps of:
 calculating the effective estradiol dosage and the effective testosterone dosage using the dosage calculation methods if the patient sex is female; and   calculating the effective testosterone dosage using the dosage calculation methods if the patient sex is male.   
     
     
         4 . The system according to  claim 2 , wherein the additional input parameters include at least one of age, height, weight, race, number of pregnancies, number of live births, number of abortions, history of renal disease, active liver disease, hysterectomy, history of cervical cancer, history of ovarian cancer, fibrocystic breast disease, history of breast cancer, current follicle stimulating hormone (FSH) level, current testosterone level, current estradiol level, current non-pellet estrodiol dose, history of acne or facial hair, history of hair loss, history of PCOS, history of hysterectomy, history of heavy menses and history of metabolic syndrome if the patient sex is female. 
     
     
         5 . The system according to  claim 4 , wherein the dosage method for a female new patient further comprises:
 receiving, by the electronic circuit, patient age and weight;   determining, by the electronic circuit, patient weight/age ratio;   determining, by the electronic circuit, a weight/age estradiol lookup, a weight testosterone lookup, an age estradiol lookup, a testosterone level lookup, a follicle stimulating hormone (FSH) lookup, and a current dose lookup;   determining, by the electronic circuit, a problem factor adjustment and an FSH adjustment, wherein the FSH adjustment is 12.5 if age greater than or equal to 30;   determining, by the electronic circuit, an estradiol dosage according to:
   estradiol dosage=((weight/age estradiol ratio lookup+age estradiol lookup+FSH lookup)×problem factor adjustment)+FSH adjustment
 
 and, 
   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=(weight testosterone ratio lookup+testosterone level lookup)×testosterone age lookup.
 
   
     
     
         6 . The system according to  claim 5 , wherein the electronic circuit if further configured to carry out the steps of:
 setting the estradiol dosage not equal to zero if the female patient is pre-menopausal and exhibits at least one of a current estradiol level less than 10 and symptoms of migraines; and   setting the estradiol dosage equal to zero if the female patient is pre-menopausal and exhibits at least one of the current estradiol level greater than 10 and no symptoms of migraines.   
     
     
         7 . The system according to  claim 5 , wherein the problem factor adjustment is a value determined as a multiplicative product of the one or more values selected from the group comprising:
 1.00 for no problem adjustment,   0.90 for history of acne or facial hair,   0.88 for history of hair loss,   0.75 for history of PCOS,   0.88 for hysterectomy,   0.70 for history of fibrocystic breast disease,   0.88 for history of heavy menses,   0.80 for persistent breast pain,   0.80 for mid-cycle bleeding,   0.75 for headaches,   0.75 for fluid retention, and   0.00 for history of metabolic syndrome.   
     
     
         8 . The system according to  claim 4 , wherein the dosage method for a female returning patient further comprises:
 receiving, by the electronic circuit, patient age and weight;   determining, by the electronic circuit, patient weight/age ratio;   determining, by the electronic circuit, a weight/age estradiol lookup, a weight testosterone lookup, an age estradiol lookup, a current estradiol dose lookup, a testosterone level lookup, a follicle stimulating hormone (FSH) lookup, and a current dose lookup;   determining, by the electronic circuit, a problem factor adjustment and an FSH adjustment;   determining, by the electronic circuit, an estradiol dosage according to:
   estradiol dosage=(weight/age estradiol ratio lookup+age estradiol lookup+FSH lookup+current estradiol dose lookup)×problem factor adjustment
 
 and, 
   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=(weight testosterone ratio lookup+testosterone level lookup)×testosterone age lookup.
 
   
     
     
         9 . The system according to  claim 8 , wherein the problem factor adjustment is a value determined as a multiplicative product of the one or more values selected from the group comprising:
 1.00 for no problem adjustment,   0.90 for history of acne or facial hair,   0.88 for history of hair loss,   0.75 for history of PCOS,   0.88 for hysterectomy,   0.70 for history of fibrocystic breast disease,   0.88 for history of heavy menses,   0.80 for persistent breast pain,   0.80 for mid-cycle bleeding,   0.75 for headaches,   0.75 for fluid retention, and   0.00 for history of metabolic syndrome.   
     
     
         10 . The system according to  claim 4 , wherein the dosage method for a female booster patient further comprises:
 receiving, by the electronic circuit, patient previous estradiol dosage, previous testosterone dosage, whether patient is pre-menopausal, estradiol level, and whether patient has migraines;   if patient is not pre-menopausal, or is pre-menopausal with estradiol level less than 10 or migraines, determining, by the electronic circuit, an estradiol dosage according to:
   estradiol dosage=previous estradiol dosage/2.00, 
   else if patient is pre-menopausal, estradiol is greater than or equal to 10 or patient has migraines, estradiol dosage=0,
 and, 
   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=previous testosterone dosage/3.00. 
   
     
     
         11 . The system according to  claim 3 , wherein the additional male input parameters comprise: age, height, weight, race, history of hypertension, history of diabetes, history of colon cancer, history of testicular cancer, history of BPH, history of prostate cancer, history of renal disease, active liver disease, and current testosterone level. 
     
     
         12 . The system according to  claim 11 , wherein the dosage method for a male new patient further comprises:
 receiving, by the electronic circuit, patient age, height, weight, race, history of hypertension, history of diabetes, history of colon cancer, history of testicular cancer, history of BPH, history of prostate cancer, history of renal disease, active liver disease and current testosterone level;   determining, by the electronic circuit, a weight lookup value, an age lookup value, a current dose lookup value, and an additional adjustment;   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=weight lookup value×age lookup value×additional adjustment.
 
   
     
     
         13 . The system according to  claim 12 , wherein the additional adjustment is a value determined as a multiplicative product of the one or more values selected from the group comprising:
 1.00 for no problem adjustment,   0.95 for history of BPH,   0.90 for history of prostate cancer,   0.90 for history of both prostate cancer and BPH, ignoring individual values for these conditions, and   0.0 if testosterone level greater than 700.   
     
     
         14 . The system according to  claim 12 , wherein the testosterone dosage is modified as indicated for:
 history of diabetes, dosage=dosage+100 mg;   sedentary patient, dosage=dosage−100 mg;   patient exercises five times/week or more, dosage=dosage+100 mg;   patient uses a testosterone gel 1.62% or greater, dosage=dosage−100 mg.   
     
     
         15 . The system according to  claim 11 , wherein the dosage calculation method for a male return patient further comprises:
 if current testosterone dosage is less than 400.00 mg, then dosage=previous testosterone dosage+200.00 mg;   else, dosage=previous testosterone dosage.   
     
     
         16 . The system according to  claim 11 , wherein the dosage calculation method for a male booster patient further comprises:
 determining, by the electronic circuit, an additional adjustment value determined as a multiplicative product of the one or more values selected from the group comprising:   1.00 for no problem adjustment,   0.95 for history of BPH,   0.90 for history of prostate cancer,   0.90 for history of both prostate cancer and BPH, ignoring individual values for these conditions, and   0.0 if testosterone level greater than 700;   determining a testosterone dosage as:
   previous testosterone dosage+0.20 mg×additional adjustment.
 
   
     
     
         17 . A method of providing a dosage on a device comprising an electronic circuit, an input device, and a display screen, the method comprising:
 receiving an input signal from the input device related to a patient sex and a patient status;   selecting dosage calculation methods to apply to the input signal, the dosage calculation methods selected based on at least one of the patient sex, the patient status, and additional input parameters;   calculating, using the electronic circuit, at least one of an effective estradiol dosage and an effective testosterone dosage based on the selected dosage calculation methods; and   displaying, on the display screen, the calculated effective dosages.   
     
     
         18 . The method according to  claim 17 , wherein selecting the dosage calculation methods based on additional input parameters includes selecting at least one of age, height, weight, race, number of pregnancies, number of live births, number of abortions, history of renal disease, active liver disease, hysterectomy, history of cervical cancer, history of ovarian cancer, fibrocystic breast disease, history of breast cancer, current follical stimulating hormone (FSH) level, current testosterone level, current estradiol level, current non-pellet estradiol dose, history of acne or facial hair, history of hair loss, history of PCOS, history of hysterectomy, history of heavy menses and history of metabolic syndrome if the patient sex is female. 
     
     
         19 . The method according to  claim 18 , wherein selecting the dosage calculation method for a female new patient further comprises:
 receiving, by the electronic circuit, patient age and weight;   determining, by the electronic circuit, patient weight/age ratio;   determining, by the electronic circuit, a weight/age estradiol lookup, a weight testosterone lookup, an age estradiol lookup, a testosterone level lookup, a follicle stimulating hormone (FSH) lookup, and a current dose lookup;   determining, by the electronic circuit, a problem factor adjustment and an FSH adjustment, wherein the FSH adjustment is 12.5 if age greater than or equal to 30;   determining, by the electronic circuit, an estradiol dosage according to:
   estradiol dosage=((weight/age estradiol ratio lookup+age estradiol lookup+FSH lookup)×problem factor adjustment)+FSH adjustment
 
 and, 
   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=(weight testosterone ratio lookup+testosterone level lookup)×testosterone age lookup.
 
   
     
     
         20 . The method according to  claim 18 , wherein selecting the dosage calculating methods for a female booster patient further comprises:
 receiving, by the electronic circuit, patient previous estradiol dosage, previous testosterone dosage, whether patient is pre-menopausal, estradiol level, and whether patient has migraines;   if patient is not pre-menopausal, or is pre-menopausal with estradiol level less than 10 or migraines, determining, by the electronic circuit, an estradiol dosage according to:
   estradiol dosage=previous estradiol dosage/2.00, 
   else if patient is pre-menopausal, estradiol is greater than or equal to 10 or patient has migraines, estradiol dosage=0,
 and, 
   determining, by the electronic circuit, an testosterone dosage according to:
   testosterone dosage=previous testosterone dosage/3.00.