Sodium containing sol-gel derived bioactive glasses and uses thereof including hemostasis

Abstract

A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof, which include introducing Na 2 O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.

1 . A sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of sodium methoxide, sodium tert-butoxide, sodium hydroxide, sodium oxalate, sodium nitrate, sodium sulfate, sodium thiosulfate, sodium dodecyl sulfate, sodium bicarbonate, soda ash, baking soda, and sodium acetate. 
     
     
         2 . The sol-gel bioactive glass precursor of  claim 1 , wherein the Si source is selected from the group consisting of tetraethylorthosilicate (TEOS), tetramethylorthosilicate (TMOS), fumed silica, colloidal silica, silica gel, sodium silicate, and silicon tetrachloride. 
     
     
         3 . The sol-gel bioactive glass precursor of  claim 1 , wherein the Ca source is selected from the group consisting of calcium methoxide, calcium chloride diydrate, calcium hydroxide, calcium oxolate hydrate, and calcium citrate tetrahydrate, calcium sulfate dehydrate, calcium carbonate, calcium acetate hydrate. 
     
     
         4 . The sol-gel bioactive glass precursor of  claim 2 , wherein the Ca source is selected from the group consisting of calcium methoxide, calcium chloride diydrate, calcium hydroxide, calcium oxolate hydrate, and calcium citrate tetrahydrate, calcium sulfate dehydrate, calcium carbonate, calcium acetate hydrate. 
     
     
         5 . The sol-gel bioactive glass precursor of  claim 1 , wherein the P source is triethylphosphate or sodium hexametaphosphate. 
     
     
         6 . The sol-gel bioactive glass precursor of  claim 1 , wherein the source of Na is present in an amount to provide for 20-30% by weight of Na 2 O in a sol-gel bioactive glass. 
     
     
         7 . The sol-gel bioactive glass precursor of  claim 2 , wherein the source of Si is present in an amount to provide for 20-30% by weight of SiO 2  in a sol-gel bioactive glass. 
     
     
         8 . The sol-gel bioactive glass precursor of  claim 3 , wherein the source of Ca is present in an amount to provide for 20-30% by weight of CaO in a sol-gel bioactive glass. 
     
     
         9 . The sol-gel bioactive glass precursor of  claim 4 , wherein the source of Ca is present in an amount to provide for 20-30% by weight of CaO in a sol-gel bioactive glass. 
     
     
         10 . The sol gel bioactive glass precursor of  claim 5 , wherein the source of phosphate is triethylphosphate and is present in an amount to provide for 20-30% by weight of P 2 O 5  in a sol-gel bioactive glass. 
     
     
         11 . The sol-gel bioactive glass of  claim 1 , wherein the bioactive sol-gel glass is in a granular form, particulate form, matt form, fiber form, hemostatic sponge form, foam form, paste or putty form, or sphere or bead form, or a combination thereof. 
     
     
         12 . A sol-gel bioactive glass comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source selected from the group consisting of sodium methoxide, sodium tert-butoxide, sodium hydroxide, sodium oxalate, sodium nitrate, sodium sulfate, sodium thiosulfate, sodium dodecyl sulfate, sodium bicarbonate, soda ash, baking soda, and sodium acetate. 
     
     
         13 . A method of making a sol-gel bioactive glass including Si, Ca, P, and Na comprising:
 mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of sodium methoxide, sodium tert-butoxide, sodium hydroxide, sodium oxalate, sodium nitrate, sodium sulfate, sodium thiosulfate, sodium dodecyl sulfate, sodium bicarbonate, soda ash, baking soda, sodium silicate, and sodium acetate;   aging the mixture, and   drying the mixture to form the sol-gel bioactive glass.   
     
     
         14 . The method of  claim 13 , wherein said aging is conducted at a temperature of 50-80° C. for 40-70 hours. 
     
     
         15 . The method of  claim 13 , further comprising sintering at 500-900° C. for 15 to 50 hours. 
     
     
         16 . A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass of  claim 12 . 
     
     
         17 . A method of inducing rapid coagulation in a bleeding patient comprising contacting the patient with the sol-gel bioactive glass of  claim 12 . 
     
     
         18 . A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass made from the sol-gel bioactive glass precursor of  claim 1 . 
     
     
         19 . The sol-gel bioactive glass of  claim 12 , wherein Si, Ca, P, and Na are present in their oxide form of SiO 2 , Ca 2 O, P 2 O 5 , and NaO. 
     
     
         20 . The sol-gel bioactive glass of  claim 19 , further comprising one or more of K, Mg, Zn, B, F, or Ag. 
     
     
         21 . A method of making a sol-gel bioactive glass including Si, Ca, P, and Na comprising:
 mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of sodium methoxide, sodium tert-butoxide, sodium hydroxide, sodium oxalate, sodium nitrate, sodium sulfate, sodium thiosulfate, sodium dodecyl sulfate, sodium bicarbonate, soda ash, baking soda, and sodium acetate, and   drying the mixture at a temperature of 100° C. or lower.   
     
     
         22 . The method of  claim 21 , further comprising adding a biologically active molecule. 
     
     
         23 . A method of treating wounds in a patient comprising contacting the patient with the sol-gel bioactive glass of  claim 12 . 
     
     
         24 . A method of repairing bone in a patient comprising contacting the bone in need of treatment with the sol-gel bioactive glass of  claim 12 . 
     
     
         25 . A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source, wherein the sodium source is selected from the group consisting of sodium methoxide, sodium tert-butoxide, sodium hydroxide, sodium oxalate, sodium nitrate, sodium sulfate, sodium thiosulfate, sodium dodecyl sulfate, sodium bicarbonate, soda ash, baking soda, and sodium acetate.