Andrographis paniculata extract

Abstract

An extract of Andrographis paniculata extract containing androgapholide, 14-deoxyandrographolide, 14-deoxy-11,12-dehydroandrographolide, neoandrographolide, polysaccharides, and flavanoids. Also disclosed is a pharmaceutical composition containing such an extract and its use for treating inflammatory bowel disease.

1 - 25 . (canceled) 
     
     
         26 . A method of effectively treating an inflammatory bowel disease in a human comprising orally administering the human in need thereof, in a solid dosage form chosen from tablets and capsules, said solid dosage form comprising
 an extract of Andrographis paniculata comprising andrographolide lactones,   wherein the andrographolide lactones in said extract comprise:   andrographolide in an amount ranging from 2% to 20% of the dry weight of the extract;   14-deoxyandrographolide in an amount ranging from greater than 0 to 2% of the dry weight of the extract;   14-deoxy-11,12-dehydrogen-andrographolide in an amount ranging from 1% to 6% of the dry weight of the extract; and   neoandrographolide in an amount ranging from 1% to 5% of the dry weight of the extract,   further wherein said solid dosage form further comprises dextrin and at least one pharmaceutically acceptable carrier, and   even further wherein the method of effectively treating an inflammatory bowel disease in a human is conducted for 8 weeks by orally administering a daily dosage of at least 1200 mg to said human.   
     
     
         27 . The method of  claim 26 , wherein said extract further comprises polysaccharides and flavonoids. 
     
     
         28 . A method of effectively treating ulcerative colitis in a human comprising orally administering the human in need thereof, in a solid dosage form chosen from tablets and capsules, said solid dosage form comprising
 an extract of Andrographis paniculata comprising andrographolide lactones,   wherein the andrographolide lactones in said extract comprise:   andrographolide in an amount ranging from 2% to 20% of the dry weight of the extract;   14-deoxyandrographolide in an amount ranging from 0.01% to 2% of the dry weight of the extract;   14-deoxy-11,12-dehydrogen-andrographolide in an amount ranging from 1% to 6% of the dry weight of the extract; and   neoandrographolide in an amount ranging from 1% to 5% of the dry weight of the extract,   further wherein said solid dosage form further comprises dextrin and at least one pharmaceutically acceptable carrier, and   even further wherein the method of effectively treating ulcerative colitis in a human is conducted for 8 weeks by orally administering a daily dosage of said solid dosage form, and   even further wherein said daily dosage, following said oral administration to said human, has been shown to be effective for treating ulcerative colitis in a human.   
     
     
         29 . The method of  claim 28 , wherein said extract further comprises polysaccharides and flavonoids. 
     
     
         30 . A method of effectively treating ulcerative colitis in a human comprising orally administering the human in need thereof, in a solid dosage form chosen from tablets and capsules, said solid dosage form comprising
 an extract of Andrographis paniculata comprising andrographolide lactones,   wherein the andrographolide lactones in said extract comprise:   andrographolide in an amount ranging from 2% to 20% of the dry weight of the extract;   14-deoxyandrographolide in an amount ranging from 0.01% to 2% of the dry weight of the extract;   14-deoxy-11,12-dehydrogen-andrographolide in an amount ranging from 1% to 6% of the dry weight of the extract; and   neoandrographolide in an amount ranging from 1% to 5% of the dry weight of the extract,   further wherein said solid dosage form further comprises at least one pharmaceutically acceptable carrier, and   even further wherein the method of effectively treating ulcerative colitis in a human is conducted for 8 weeks by orally administering to said human a dosage effective for treating said ulcerative colitis in said human, and   even further wherein said solid dosage form, following said oral administration to said human, shows efficacy in treating said ulcerative colitis.   
     
     
         31 . The method of  claim 30 , wherein said extract further comprises polysaccharides and flavonoids. 
     
     
         32 . A method of effectively treating inflammatory bowel disease in a human comprising orally administering the human in need thereof, in a solid dosage form chosen from tablets and capsules, said solid dosage form comprising
 an extract of Andrographis paniculata comprising andrographolide lactones,   wherein the andrographolide lactones in said extract comprise:   andrographolide in an amount ranging from 2% to 20% of the dry weight of the extract;   14-deoxyandrographolide in an amount ranging from 0.01% to 2% of the dry weight of the extract;   14-deoxy-11,12-dehydrogen-andrographolide in an amount ranging from 1% to 6% of the dry weight of the extract; and   neoandrographolide in an amount ranging from 1% to 5% of the dry weight of the extract,   further wherein said solid dosage form further comprises at least one pharmaceutically acceptable carrier, and   even further wherein the method of effectively treating inflammatory bowel disease in a human is conducted for 8 weeks by orally administering to said human a dosage effective for treating said inflammatory bowel disease in said human.   
     
     
         33 . The method of  claim 32 , wherein said extract further comprises polysaccharides and flavonoids.