US2014323693A1PendingUtilityA1

Antibodies To Non-Functional P2X7 Receptor

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Assignee: BIOSCEPTRE INT LTDPriority: Jan 17, 2001Filed: Mar 18, 2014Published: Oct 30, 2014
Est. expiryJan 17, 2021(expired)· nominal 20-yr term from priority
Inventors:Julian Alexander BardenAngus Gidley-Baird
A61P 31/06A61P 31/00A61P 31/04A61P 43/00A61P 35/00A61P 31/18A61P 31/12A61P 1/00G01N 33/6872C07K 14/705C07K 16/3069A61K 2039/505C07K 16/3015G01N 2800/065C07K 16/3046C07K 16/28C07K 2317/73C07K 16/3053C07K 14/4747C07K 16/3023C07K 16/3038C07K 16/30C07K 2317/30
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Claims

Abstract

The present invention provides antibodies that specifically bind to P2X7 receptors and distinguish between functional and non-functional p2X7 receptors, pharmaceutical compositions and kits containing the antibodies, and methods of using the antibodies for the detection, diagnosis and treatment of disease conditions.

Claims

exact text as granted — not AI-modified
We claim: 
     
         1 . An isolated P2X 7  receptor having an amino acid sequence that has homology to the sequence shown in SEQ ID NO: 1, wherein
 the amino acid sequence of the isolated P2X 7  receptor contains a proline corresponding to proline at position 210 as shown in SEQ ID NO: 1, said proline being in a cis conformation.   
     
     
         2 . The receptor of  claim 1 , wherein the receptor is a rodent receptor. 
     
     
         3 . The receptor of  claim 2 , where in the receptor is selected from the group consisting of a mouse, rat and rabbit receptor. 
     
     
         4 . An isolated P2X 7  receptor having an amino acid sequence as shown in SEQ ID NO: 1, wherein the proline at position 210 is in a cis conformation.

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