US2014323706A1PendingUtilityA1

Nucleic acids encoding receptor for il-17 homologous polypeptides and uses thereof

Assignee: GENENTECH INCPriority: Aug 24, 2000Filed: Mar 25, 2013Published: Oct 30, 2014

Est. expiryAug 24, 2020(expired)· nominal 20-yr term from priority

Inventors:Jian Chen Ellen Filvaroff Sherman Fong Audrey Goddard Paul Godowski Christopher Grimaldi Austin Gurney Hanzhong Li Kenneth Hillan Daniel Tumas Menno Vanlookeren Richard Vandlen Colin Watanabe P. Williams William I. Wood Daniel Yansura

G01N 33/57535G01N 33/57515G01N 33/5752C07K 14/54C07K 14/705A61K 38/00G01N 2500/04

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References

Claims

Abstract

The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.

Claims

exact text as granted — not AI-modified

1 . Isolated nucleic acid having at least 80% nucleic acid sequence identity to:
 (a) a nucleotide sequence encoding the polypeptide shown in  FIG. 2  (SEQ ID NO:2),  FIG. 4  (SEQ ID NO:4),  FIG. 6  (SEQ ID NO:6),  FIG. 8  (SEQ ID NO:8),  FIG. 12  (SEQ ID NO:12),  FIG. 14  (SEQ ID NO:14),  FIG. 16  (SEQ ID NO:16), or  FIG. 18  (SEQ ID NO:18);   (b) a nucleotide sequence encoding the polypeptide shown in FIG. 2 (SEQ ID NO:2),  FIG. 4  (SEQ ID NO:4),  FIG. 6  (SEQ ID NO:6),  FIG. 8  (SEQ ID NO:8),  FIG. 12  (SEQ ID NO:12),  FIG. 14  (SEQ ID NO:14),  FIG. 16  (SEQ ID NO:16), or  FIG. 18  (SEQ ID NO:18), lacking its associated signal peptide;   (c) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in  FIG. 2  (SEQ ID NO:2),  FIG. 4  (SEQ ID NO:4),  FIG. 6  (SEQ ID NO:6),  FIG. 8  (SEQ ID NO:8),  FIG. 12  (SEQ ID NO:12),  FIG. 14  (SEQ ID NO:14),  FIG. 16  (SEQ ID NO:16), or  FIG. 18  (SEQ ID NO:18), with its associated signal peptide; or   (d) a nucleotide sequence encoding an extracellular domain of the polypeptide shown in  FIG. 2  (SEQ ID NO:2),  FIG. 4  (SEQ ID NO:4),  FIG. 6  (SEQ ID NO:6),  FIG. 8  (SEQ ID NO:8),  FIG. 12  (SEQ ID NO:12),  FIG. 14  (SEQ ID NO:14),  FIG. 16  (SEQ ID NO:16), or  FIG. 18  (SEQ ID NO:18), lacking its associated signal peptide.   
     
     
         2 - 60 . (canceled)

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