Antibacterial and antifungal substances biphenylyl compounds

Abstract

The invention relates to the use of a substance of the general form (I) to produce an antibacterial and/or antifungal drug, wherein X is a methylene group or a carbonyl group; R 1 , R 2 , and R 3 are each selected from the group comprising hydrogen, an alkyl group having a chain length of 1-4 carbon atoms, an alkoxy group having a chain length of 1-3 carbon atoms, and a halogen; R 4 and R 5 are each selected from the group comprising hydrogen and an alkyl group having a chain length of 1-4 carbon atoms; and n=3 to 6.

1 . A substance of the general formula 
       
         
           
           
               
               
           
         
       
       for use as antibacterial and/or antifungal drug, wherein
 X is a methylene or a carbonyl group; 
 R 1 , R 2  and R 3  are each selected from the group consisting of hydrogen, an alkyl group having a chain length of 1-4 carbon atoms, an alkoxy group with a chain length of 1-3 carbon atoms, and a halogen; 
 R 4  and R 5  are each selected from the group consisting of hydrogen and an alkyl group with a chain length of 1-4 carbon atoms; and 
 n=3 to 6. 
 
     
     
         2 . The substance of  claim 1 , wherein the substance is available as a hydrochloride, a salt, or as a tautomer. 
     
     
         3 . The substance of  claim 1 , wherein the alkyl group is a methyl (CH 3 )—, an ethyl (CH 2 CH 3 )—, a propyl (CH 2 CH 2 CH 3 )—, an isopropyl (CHCH 3 CH 3 )—, a butyl (CH 2 CH 2 CH 2 CH 3 )—, an isobutyl (CHCH 3 CH 2 CH 3 )— or a tertiary butyl (CCH 3 CH 3 CH 3 )— group. 
     
     
         4 . The substance of  claim 1 , wherein the alkoxy group is a methoxy (OCH 3 )—, an ethoxy (OCH 2 CH 3 )—, a propoxy (OCH 2 CH 2 CH 3 )— or an isopropoxy (OCHCH 3 CH 3 )— group. 
     
     
         5 . The substance of  claim 1 , wherein the halogen is fluorine (F), chlorine (Cl), bromine (Br), or iodine (I). 
     
     
         6 . The substance of  claim 1 , wherein the water-solubility of the substance is equal to or greater than 1,000 mg/l. 
     
     
         7 . The substance of  claim 1 , wherein the water-solubility of the substance is equal to or greater than 5,000 mg/l. 
     
     
         8 . The substance of  claim 1 , wherein the water-solubility of the substance is equal to or greater than 10,000 mg/l. 
     
     
         9 . The substance of  claim 1 , wherein the substance is  4′(4-bromphenyl)-4-dimethylaminobutyrophenonhydrochloride with the structural formula 
       
         
           
           
               
               
           
         
       
     
     
         10 . The substance of  claim 1 , wherein the substance is
 4-brom-4′-(4-dimethylaminobutyl)biphenylhydrochloride with the structural formula