Family of Silver (I) Periodate Compounds Having Broad Microbial Properties

Abstract

The present application discloses a method of making a surface antimicrobial by coating or forming a surface with a silver (I) periodate as well as articles of manufacture comprising a silver (I) periodate. The present application also discloses a method of preventing or reducing microbial contamination on a substrate by coating the substrate with at least one silver (I) periodate. The substrate can be a wound dressing, a medical instrument, a medical device, a metallic article, a plant or a seed.

1 . An article of manufacture comprising an antimicrobial silver (I) periodate. 
     
     
         2 . The article of manufacture wherein the silver (I) periodate is one or more compounds selected from the group consisting of silver (I) iodate; pentasilver hexaoxoiodate; Ag 5 IO 6 ; silver orthoperiodate; silver periodate (VII); silver iodate (VII); 5 Ag 2 O.I 2 O 7 ; Ag 2 H 3 IO 6 ; Ag x H y IO 6 , where x+y=5; Ag x M y IO 6 , where the total cationic charge of x+y=5 and M is a cation; and combinations thereof. 
     
     
         3 . The article of manufacture of  claim 2  wherein the cation is selected from the group consisting of K, Na, Mg, Ca, Au, Pt, Cu, and Fe., 
     
     
         4 . The article of manufacture of  claim 1  wherein the article is a wound dressing, a medical instrument, a medical device, a metallic article, or a portion thereof. 
     
     
         5 - 7 . (canceled) 
     
     
         8 . A method of preventing or reducing microbial contamination on a substrate comprising coating a substrate with one or more silver(I) periodates. 
     
     
         9 . The method of  claim 8  wherein the silver (I) periodate is one or more compounds selected from the group consisting of silver (I) iodate; pentasilver hexaoxoiodate; Ag 5 IO 6 ; silver orthoperiodate; silver periodate (VII); silver iodate (VII); 5 Ag 2 O.I 2 O 7 ; Ag 2 H 3 IO 6 ; Ag x H y IO 6 , where x+y=5; Ag x M y IO 6 , where the total cationic charge of x+y=5 and M is a cation; and combinations thereof. 
     
     
         10 . The method of  claim 8  wherein the substrate is a wound dressing, a medical instrument, a medical device, a metallic article, a plant, a seed, or a portion thereof. 
     
     
         11 . An antimicrobial wound dressing comprising an antimicrobial coating containing one or more silver (I) periodates. 
     
     
         12 . The wound dressing of  claim 11  wherein the silver (I) periodate is one or more compounds selected from the group consisting of silver (I) iodate; pentasilver hexaoxoiodate; Ag 5 IO 6 ; silver orthoperiodate; silver periodate (VII); silver iodate (VII); 5 Ag 2 O.I 2 O 7 ; Ag 2 H 3 IO 6 ; Ag x H y IO 6 , where x+y=5; Ag x M y IO 6 , where the total cationic charge of x+y=5 and M is a cation; and combinations thereof. 
     
     
         13 . The wound dressing of  claim 11  wherein one or more silver (I) periodates are coated onto a wound dressing fiber. 
     
     
         14 - 15 . (canceled)