Lactobacillus plantarum inducia dsm 21379 as enhancer of cellular immunity, hypocholesterolemic and anti-oxidative agent and antimicrobial agent against clostridium difficile

Abstract

A microorganism strain Lactobacillus plantarum Inducia DSM 21379 for use as hypocholesterolemic, antimicrobial and anti-oxidative agent and as enhancer of the natural defense potential of a subject. L. plantarum Inducia is used for reducing the level of LDL-cholesterol in blood for preventing the cholesterol metabolism disorders and cardiovascular disorders. L. plantarum Inducia enhances simultaneously the natural defense potential and cellular immunity, and as anti-oxidative agent enhances anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL). The strain is also used as an antimicrobial agent for lowering risk of Clostridium difficile associated diarrhoeae (CDAD) by preventing germination of C. difficile spores and by suppressing proliferation of its vegetative cells. The compositions comprising L. plantarum Inducia decrease the levels of LDL-cholesterol and ox-LDL in blood, enhance the natural defense potential and lower risk of CDAD. The composition may further comprise xylitol.

What is claimed is: 
     
         1 . A composition comprising the probiotic microorganism  Lactobacillus plantarum  Inducia DSM 21379
 for enhancing the natural defense potential and cellular immunity of a subject, and simultaneously for use in preventing the cholesterol metabolism disorders and consecutive cardiovascular disorders by decreasing the level of LDL-cholesterol in blood, and simultaneously   for enhancing anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL).   
     
     
         2 . The composition of  claim 1 , which is selected from the group consisting a pharmaceutical composition, a food composition, a food supplement composition and a veterinary composition. 
     
     
         3 . A food product comprising the composition of  claim 1 . 
     
     
         4 . The food product according to  claim 3 , wherein the food product is a dairy product. 
     
     
         5 . The food product according to  claim 4 , wherein the food product is a fermented milk product. 
     
     
         6 . The food product according to  claim 5 , wherein the food product is cheese. 
     
     
         7 . The food product according to  claim 5 , wherein the food product is yoghurt. 
     
     
         8 . The composition comprising the probiotic microorganism  Lactobacillus plantarum  Inducia DSM 21379 for use in lowering risk of  Clostridium difficile  associated diarrhoeae (CDAD) by preventing germination of  Clostridium difficile  spores and suppressing proliferation of  Clostridium difficile  vegetative cells. 
     
     
         9 . The composition of  claim 8 , which is selected from the group consisting a pharmaceutical composition, a food composition, a food supplement composition and a veterinary composition. 
     
     
         10 . The composition of  claim 9  further comprising xylitol. 
     
     
         11 . The food product comprising the composition of  claim 10 . 
     
     
         12 . The food product of  claim 11 , wherein the food product is a dairy product. 
     
     
         13 . The food product of  claim 12 , wherein the food product is a fermented milk product. 
     
     
         14 . The food product according to  claim 12 , wherein the food product is cheese. 
     
     
         15 . The food product according to  claim 12 , wherein the food product is yoghurt. 
     
     
         16 .  Lactobacillus plantarum  Inducia DSM 21379 for use as hypocholesterolemic agent by decreasing the level of LDL-cholesterol in blood for preventing cholesterol metabolism disorders and consecutive cardiovascular disorders, and simultaneously for use as anti-oxidative agent for enhancing anti-oxidative activity of blood by reducing the level of oxidized low density lipoprotein (ox-LDL) and by enhancing the total anti-oxidative activity (TAA) of a composition comprising said strain, and simultaneously for use as enhancer of the natural defense potential and cellular immunity of a subject. 
     
     
         17 .  Lactobacillus plantarum  Inducia DSM 21379 for use as antimicrobial agent by preventing germination of  Clostridium difficile  spores and suppressing proliferation of  Clostridium difficile  vegetative cells for lowering risk of  Clostridium difficile  associated diarrhoeae (CDAD). 
     
     
         18 .  Lactobacillus plantarum  Inducia DSM 21379 for use according to  claim 17  together with xylitol.