Il-17 binding proteins

Abstract

Proteins that bind IL-17 and/or IL-17F are described along with there use in composition and methods for treating, preventing, and diagnosing IL-17 related diseases and for detecting IL-17 in cells, tissues, samples, and compositions.

1 - 102 . (canceled) 
     
     
         103 . An isolated nucleic acid encoding a binding protein amino acid sequence, wherein the binding protein comprises an antigen binding domain capable of binding human IL-17, wherein the antigen binding domain comprises at least one CDR comprising an amino acid sequence selected from the group consisting of:
 CDR-H1. X 1 -X 2 -X 3 -X 4 -X 5  (SEQ ID NO:925), wherein;
 X 1  is N, A, D, or S; 
 X 2  is Y, F, or L; 
 X 3  is G, D, or A; 
 X 4  is M or I; and 
 X 5  is H, D, or S; 
   CDR-H2. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 -X 15 -X 16 -X 17  (SEQ ID NO:926), wherein;   X 1  is V, W, or G;   X 2  is I, T, M, or F;   X 3  is S, N, T, or D;   X 4  is Y or P;   X 5  is D, N, or I;   X 6  is G, S, L, or E;   X 7  is S or G;   X 8  is N, T, or E;   X 9  is K, T, or A;   X 10  is Y, G, N, or V;   X 11  is Y or V;   X 12  is A;   X 13  is D, P, or Q;   X 14  is S, K, or N;
 X 15  is V or F; 
 X 16  is K, R, or Q; and 
 X 17  is G; 
   CDR-H3. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13 -X 14 -X 15 -X 16 -X 17  (SEQ ID NO:927), wherein;
 X 1  is V, S, E, or I; 
 X 2  is G, S, P, or R; 
 X 3  is A, E, N, or P; 
 X 4  is S, D, or W; 
 X 5  is G, E, F, or L; 
 X 6  is D, G, or W; 
 X 7  is Y, I, N, or G; 
 X 8  is Y, T, G, or A; 
 X 9  is Y or I; 
 X 10  is S, G, or Y; 
 X 11  is Y, F, or T; 
 X 12  is G, T, or is not present; 
 X 13  is L, H, or is not present; 
 X 14  is H or is not present; 
 X 15  is F or is not present; 
 X 16  is D; and 
 X 17  is V, N, or Y; 
   CDR-L1. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11 -X 12 -X 13  (SEQ ID NO:928), wherein;
 X 1  is S, R, or K; 
 X 2  is G or A; 
 X 3  is S or D; 
 X 4  is N, K, or Q; 
 X 5  is S or is not present; 
 X 6  is N or is not present; 
 X 7  is I, L, N, or D; 
 X 8  is G or I; 
 X 9  is S, N, G, or D; 
 X 10  is H, R, S, or D; 
 X 11  is S, Y, A, or D; 
 X 12  is V, A, L, or M; and 
 X 13  is N, C, or H; 
   CDR-L2. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7  (SEQ ID NO:929), wherein;
 X 1  is G, Q, Y, or E; 
 X 2  is I, D, or A; 
 X 3  is G, N, S, or T; 
 X 4  is Q, K, or T; 
 X 5  is R, S, or L; 
 X 6  is P, I, or V; and 
 X 7  is S or P; 
   and   CDR-L3. X 1 -X 2 -X 3 -X 4 -X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -X 11  (SEQ ID NO:930), wherein;
 X 1  is A, Q, H, or L; 
 X 2  is T or Q; 
 X 3  is W, S, or H; 
 X 4  is D or T; 
 X 5  is D or S; 
 X 6  is S, T, L, or F; 
 X 7  is L, T, or P; 
 X 8  is G, H, or Y; 
 X 9  is G, S, or T; 
 X 10  is Y or is not present; and 
 X 11  is V or is not present; 
   a CDR-H1, a CDR-H2, and a CDR-H3 of any variable heavy region (VH) in Table 21, Table 23, Table 24, or Table 27; and   a CDR-L1, a CDR-L2, and a CDR-L3 of any variable light region (VL) in Table 21, Table 23, Table 25, or Table 27.   
     
     
         104 . A vector comprising an isolated nucleic acid of  claim 103 . 
     
     
         105 . (canceled) 
     
     
         106 . A host cell comprising the vector of  claim 104 . 
     
     
         107 - 115 . (canceled) 
     
     
         116 . A method of producing a binding protein that binds human IL-17, comprising culturing the host cell of  claim 106  in a culture medium under conditions sufficient to produce a binding protein that binds human IL-17. 
     
     
         117 - 201 . (canceled) 
     
     
         202 . An isolated nucleic acid encoding a binding protein amino acid sequence, wherein the binding protein is capable of binding human IL-17, and wherein the binding protein comprises:
 an Ig constant heavy region having an amino acid sequence selected from the group consisting of SEQ ID NO:3 and SEQ ID NO: 4;   an Ig constant light region having an amino acid sequence selected from the group consisting of SEQ ID NO:5 and SEQ ID NO: 6;   an Ig variable heavy region having an amino acid sequence of a VH in Table 21, Table 23, Table 24, or Table 27; and   an Ig variable light region having an amino acid sequence of a VL in Table 21, Table 23, Table 25, or Table 27.   
     
     
         203 . A vector comprising an isolated nucleic acid of  claim 202 . 
     
     
         204 . A host cell comprising a vector of  claim 203 . 
     
     
         205 . A method of producing a binding protein that binds human IL-17, comprising culturing the host cell of  claim 204  in a culture medium under conditions sufficient to produce a binding protein that binds human IL-17. 
     
     
         206 . An isolated nucleic acid encoding a binding protein amino acid sequence, wherein the binding protein is capable of binding human IL-17, the binding protein comprising:
 an Ig constant heavy region having an amino acid sequence of SEQ ID NO:3;   an Ig constant light region having an amino acid sequence of SEQ ID NO:5;   an Ig variable heavy region having an amino acid sequence of a VH in Table 21, Table 23, Table 24, or Table 27; and   an Ig variable light region having an amino acid sequence of a VL in Table 21, Table 23, Table 25, or Table 27.   
     
     
         207 . A vector comprising an isolated nucleic acid of  claim 206 . 
     
     
         208 . A host cell comprising a vector of  claim 207 . 
     
     
         209 . A method of producing a binding protein that binds human IL-17, comprising culturing the host cell of  claim 208  in a culture medium under conditions sufficient to produce a binding protein that binds human IL-17.