US2014342047A1PendingUtilityA1

Embedded Liquid Lubricants for Tableting

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Assignee: WYETH LLCPriority: Apr 16, 2007Filed: Aug 1, 2014Published: Nov 20, 2014
Est. expiryApr 16, 2027(~0.7 yrs left)· nominal 20-yr term from priority
Inventors:Yong Jun DaiAlan M. GoldbergMichael A. GoodeRaymond Alan BartolucciJames O. Frazier
A61P 3/02A23L 29/10A23L 29/035A23P 10/28A23L 33/40A23L 33/10A23L 33/115A23L 33/15A61K 9/2095A61K 9/20A23L 33/16A23P 10/10A23P 10/25A23V 2002/00A23L 1/304A23L 1/0315A23L 1/296A23L 1/302
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PatentIndex Score
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Cited by
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References
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Claims

Abstract

The invention provides a nutritional supplement and/or pharmaceutical composition for tableting comprising an embedded lubrication matrix. The embedded lubrication matrix comprises an oily liquid finely dispersed in an oil insoluble material. A method of lubricating a nutritional supplement or pharmaceutical composition for tableting using a matrix with embedded lubrication is also provided.

Claims

exact text as granted — not AI-modified
1 . A nutritional supplement tablet composition comprising an embedded lubrication matrix wherein the embedded lubrication matrix comprises an oily liquid finely dispersed in an oil insoluble material, and wherein the nutritional supplement composition is substantially free of stearate. 
     
     
         2 . The nutritional supplement tablet composition of  claim 1 , wherein the oily liquid is selected from the group consisting of Vitamin E. animal oil, synthetic oil, mineral oil, polyethylene glycol, silicon oil and combinations thereof. 
     
     
         3 . The nutritional supplement tablet composition of  claim 2 , wherein the oily liquid is Vitamin E acetate. 
     
     
         4 . The nutritional supplement tablet composition of  claim 1 , wherein the oil-insoluble material is selected from the group consisting of starch, dextrin, microcrystalline cellulose, ethylcelulose, gelatin, sugars, glucose, maltose, fructose, sorbitol, sucrose, mannitol, sorbitol, lactose, methylcellulose, hydroxypropylmethyl cellulose, maltodextrin, silicon dioxide, anhydrous dicalcium phosphate, and combinations thereof. 
     
     
         5 . The nutritional supplement tablet composition of  claim 1 , wherein the composition further comprises at least one mineral. 
     
     
         6 . The nutritional supplement tablet composition of  claim 1 , wherein the composition further comprises at least one vitamin. 
     
     
         7 . The nutritional supplement composition of  claim 1 , wherein the composition further comprises at least one nutritional agent. 
     
     
         8 . The nutritional supplement tablet composition of  claim 7 , wherein the at least one nutritional agent is selected from the group consisting of carotenoids, fiber, phytosterols, glucosides, polyphenols, B complex related compounds, omega-3 fatty acids, probiotics, glucosamine, herbals, amino acids, peptides, and combinations thereof. 
     
     
         9 . The nutritional supplement tablet composition of  claim 1 , further composing at least one vitamin and at least one mineral. 
     
     
         10 . The nutritional supplement tablet composition of  claim 1 , wherein the composition is a direct compression composition. 
     
     
         11 . The nutritional supplement tablet composition of  claim 1 , wherein the composition comprises a granulation. 
     
     
         12 . A multivitamin and mineral composition comprising an embedded lubrication matrix wherein the embedded lubrication matrix comprises an oily liquid finely dispersed in an oil insoluble material, and therein the tablet composition is substantially free of stearate. 
     
     
         13 . The multivitamin and mineral composition of  claim 12 , wherein the oily liquid is selected from the group consisting of Vitamin E, animal oil, synthetic oil, mineral oil, polyethylene glycol, silicon oil and combinations thereof. 
     
     
         14 . The multivitamin and mineral composition of  claims 13 , wherein the oily liquid is Vitamin E acetate. 
     
     
         15 . The multivitamin and mineral composition of  claim 12 , wherein the oil-insoluble material is selected from the group consisting of starch, dextrin, microcrystalline cellulose, ethylcelulose, gelatin, sugars, glucose, maltose, fructose, sorbitol, sucrose, mannitol, sorbitol, lactose, methylcellulose, hydroxypropylmethyl cellulose, maltodextrin, silicon dioxide, anhydrous dicalcium phosphate, and combinations thereof. 
     
     
         16 . The multivitamin and mineral composition of  claim 12 , wherein the composition further comprises at least one nutritional agent. 
     
     
         17 . The multivitamin and mineral composition of  claim 16 , wherein the at least one nutritional agent is selected from the group consisting of carotenoids, fiber, phytosterols, glucosides, polyphenols, B complex related compounds, omega-3 fatty acids, probiotics, glucosamine, herbals, amino acids, peptides, and combinations thereof. 
     
     
         18 . The multivitamin and mineral composition of  claim 12 , wherein the composition is a direct compression composition. 
     
     
         19 . The multivitamin and mineral composition of  claim 12 , wherein the composition comprises a granulation. 
     
     
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         28 . A method of lubricating a nutritional supplement composition comprising providing a matrix with embedded liquid lubricant, providing a nutritional supplement composition, mixing the matrix with embedded liquid lubricant and the nutritional supplement composition, and forming a tablet, wherein the nutritional supplement composition is substantially free of stearate. 
     
     
         29 . (canceled) 
     
     
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         33 . (Cancelled 
     
     
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         47 . (canceled)

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