Adjuvant to thrombolytic therapy for the treatment of frostbite

Abstract

A method of treating frostbite in a subject using a water-soluble cocrystal composition which contains a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer.

What is claimed is: 
     
         1 . A method of treating frostbite in a subject by administering to the subject an effective amount of a water-soluble composition comprising: a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine. 
     
     
         2 . The method of  claim 1 , wherein said quantity of acetylsalicylic acid comprises about 50% by weight of said mixture. 
     
     
         3 . The method of  claim 1 , wherein said mixture has an aqueous solubility of at least about 9.0 mg/mL. 
     
     
         4 . The method of  claim 1 , wherein said mixture has an aqueous solubility of at least about 9.4 mg/mL. 
     
     
         5 . The method of  claim 1 , wherein said mixture further comprises a sugar alcohol. 
     
     
         6 . The method of  claim 5 , wherein said sugar alcohol has an L-configuration. 
     
     
         7 . The method of  claim 1 , wherein said water soluble composition is employed as an adjuvant to thrombolytic therapy. 
     
     
         8 . The method of  claim 1 , wherein said treatment is achieved by an administration means selected from the group consisting of intravenous route, intramuscular route, intradermal route, subcutaneous route, intraperitoneal route, intraarticular route, sublingual route, subconjunctival route, and intravitreal route. 
     
     
         9 . A method of treating frostbite in a subject by administering to the subject an effective amount of a water-soluble composition comprising a cocrystal composition containing a quantity of acetylsalicylic acid and a quantity of L-Theanine, the composition made by a process comprising the steps of:
 providing a quantity of acetylsalicylic acid;   adding a quantity of L-Theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said quantity of L-Theanine;   dissolving said mixture in a quantity of a solvent to form a solution; and   drying said solution for a length of time sufficient to produce a dried crystalline mass of an aspirin-theanine cocrystal composition.   
     
     
         10 . The method of  claim 9 , wherein said treatment is achieved by an administration means selected from the group consisting of intravenous route, intramuscular route, intradermal route, subcutaneous route, intraperitoneal route, intraarticular route, sublingual route, subconjunctival route, and intravitreal route. 
     
     
         11 . The method of  claim 9 , wherein said water soluble composition is employed as an adjuvant to thrombolytic therapy. 
     
     
         12 . A method of treating frostbite in a subject by administering to the subject an effective amount of a water-soluble aspirin-theanine cocrystal composition, the composition made by a method comprising the steps of:
 providing a quantity of acetylsalicylic acid;   adding a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said enantiomer of theanine;   wetting said mixture; and   grinding said mixture for a length of time sufficient to produce a dried crystalline mass.   
     
     
         13 . The method of  claim 12 , wherein said treatment is achieved by an administration means selected from the group consisting of intravenous route, intramuscular route, intradermal route, subcutaneous route, intraperitoneal route, intraarticular route, sublingual route, subconjunctival route, and intravitreal route. 
     
     
         14 . The method of  claim 12 , wherein said water soluble composition is employed as an adjuvant to thrombolytic therapy. 
     
     
         15 . A method of treating frostbite in a subject by administering to the subject an effective amount of a water-soluble aspirin-theanine cocrystal composition, the composition made by a method comprising the steps of:
 providing a quantity of acetylsalicylic acid;   adding a quantity of a theanine enantiomer selected from the group consisting of L-theanine, D-theanine, and DL-theanine to said quantity of acetylsalicylic acid to form a mixture comprising said quantity of acetylsalicylic acid and said quantity of a theanine enantiomer;   dissolving said mixture in a quantity of a solvent to form a solution; and   drying said solution for a length of time sufficient to produce a dried crystalline mass of an aspirin-theanine cocrystal composition.   
     
     
         16 . The method of  claim 15 , wherein said water soluble composition is employed as an adjuvant to thrombolytic therapy. 
     
     
         17 . The method of  claim 15 , wherein said treatment is achieved by an administration means selected from the group consisting of intravenous route, intramuscular route, intradermal route, subcutaneous route, intraperitoneal route, intraarticular route, sublingual route, subconjunctival route, and intravitreal route.