Antimicrobial compounds and methods of use

Abstract

The present disclosure provides antimicrobial compounds, compositions comprising such antimicrobial compounds, and methods of their use, in particular, antibacterial compounds and antifungal compounds. In certain aspects, the antimicrobial compounds are effective against pathogens of hospital-acquired infections. In certain aspects, the antimicrobial compounds are effective against pathogens that are resistant to antibiotics. The antimicrobial compounds can be used in antibacterial compositions, antifungal compositions, antiseptic compositions and disinfectant compositions. The antimicrobial compounds can be used as adjuncts in antibacterial compositions and antifungal compositions.

1 . The compound of Formula I: 
       
         
           
           
               
               
           
         
       
       where n is an integer from 6-12 inclusive; R 1 , and R 2 , are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C 1 -C 10  alkyl, CH 3 , CHOHCH 3 , CH(CH 3 ) 2 , CH 2 C 6 H 6 , and CH 2 CH(CH 3 ) 2 ; R 3 , and R 4 , are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C 1 -C 10  alkyl, C 6 -C 10  aryl or C 6 -C 10  heteroaryl, CH 3 , CH(CH 3 ) 2 , CH 2 CHOH, CH 2 CH(CH 3 ) 2 , and (CH 2 ) 2 N(CH 2 CH 3 ) 2 ; R 5 , and R 6 , are the same or different and are selected independently from the group consisting of H and CH 3 , and pharmaceutically acceptable salts thereof. 
     
     
         2 - 32 . (canceled) 
     
     
         33 . A compound selected from the group consisting of: 
       
         
           
           
               
               
           
         
       
       and pharmaceutically acceptable salts thereof. 
     
     
         34 . A disinfectant composition comprising an effective amount of at least one compound of  claim 33  and a suitable carrier. 
     
     
         35 . A compound of Formula I: 
       
         
           
           
               
               
           
         
       
       where n is an integer from 6-12 inclusive; R 1 , and R 2 , are the same or different and are selected independently from the group consisting of H, substituted or unsubstituted, straight or branched chain C 1 -C 10  alkyl, CH 3 , CHOHCH 3 , CH(CH 3 ) 2 , CH 2 C 6 H 6 , and CH 2 CH(CH 3 ) 2 ; R 3  is H; R 4  is selected from the group consisting of straight or branched chain C 1 -C 10  alkyl; R 5 , and R 6 , are the same or different and are selected independently from the group consisting of H and CH 3 , and pharmaceutically acceptable salts thereof. 
     
     
         40 . The compound of claim  37 , wherein R 4  is CH 3 , CH(CH 3 ) 2 , and CH 2 CH(CH 3 ) 2 . 
     
     
         41 . A compound selected from 
       
         
           
           
               
               
           
         
         pharmaceutically acceptable salts thereof. 
       
     
     
         42 . A disinfectant composition comprising an effective amount of at least one compound of claim  39  and a suitable carrier.