Device for Monitoring Blood Flow to the Brain

Abstract

A method of estimating blood flow in a brain, comprising: a) causing currents to flow inside the head by producing electric fields inside the head; b) measuring at least changes in the electric fields and the currents; c) estimating changes in the blood volume of the head, using the measurements of the electric fields and the currents, where the current are produced in children or using electrodes at or near holes in the skull. Optionally, the configuration is selected to focus the flow of current to be inside the brain to a significant degree.

1 - 44 . (canceled) 
     
     
         45 . An apparatus for estimating blood flow to a brain, the apparatus comprising:
 a controller configured to:   receive an electrical signal from at least a first pair of electrodes adapted to engage a subject's head when electricity flows between at least a second pair of electrodes adapted to engage with the subject's head;   measure the electrical signal;   generate at least one impedance measurement of variation associated with a pulse cycle usable to estimate the rate of blood flow to the brain from the measured electrical signal;   generate an average impedance measurement;   receive a signal indicative of a pulse rate; and   estimate the rate of blood flow to the brain based on the at least one impedance measurement, the average impedance measurement, the signal indicative of the pulse rate, and an estimate of a total brain blood volume.   
     
     
         46 . The apparatus according to  claim 45 , wherein a total spread of the first pair of electrodes and the second pair of electrodes on a side of the head is at least 1 cm. 
     
     
         47 . The apparatus according to  claim 45 , wherein a total spread of the first pair of electrodes and the second pair of electrodes on a side of the head is at least 2 cm. 
     
     
         48 . The apparatus according to  claim 45 , wherein a total spread of the first pair of electrodes and the second pair of electrodes on a side of the head is at least 5 cm. 
     
     
         49 . The apparatus according to  claim 45 , further comprising at least one structure through which at least one of the first pair of electrodes is mechanically connected to at least one of the second pair of electrodes. 
     
     
         50 . The apparatus according to  claim 49 , wherein the at least one structure is rigid. 
     
     
         51 . The apparatus according to  claim 45 , wherein the at least one impedance measurement includes a measurement of impedance amplitude. 
     
     
         52 . The apparatus according to  claim 45 , wherein the at least one impedance measurement includes a measurement of impedance phase and the estimate of the rate of blood flow to the brain is further based on the measurement of impedance phase. 
     
     
         53 . The apparatus according to  claim 45 , wherein the electricity flow includes an alternating current signal component of between 40 kHz and 100 kHz. 
     
     
         54 . The apparatus according to  claim 45 , further comprising an accelerometer configured to detect head movement, wherein the at least one controller is further configured to reduce motion artifacts using data from the accelerometer. 
     
     
         55 . The apparatus according to  claim 45 , further comprising a monitor configured to display information related to the estimated blood flow. 
     
     
         56 . The apparatus according to  claim 55 , wherein the monitor is further configured to alert a user to a significant change in estimated blood flow. 
     
     
         57 . The apparatus according to  claim 45 , wherein the at least one controller is further configured to reduce motion artifacts based on the signal indicative of the pulse rate. 
     
     
         58 . The apparatus according to  claim 45 , wherein the controller is further configured to estimate the rate of blood flow to the brain using a calibration relationship between the at least one impedance measurement, the average impedance measurement, the estimate of total brain blood volume, and a change in blood volume over a pulse cycle. 
     
     
         59 . A method of estimating blood flow in the brain of a subject, the method comprising:
 causing currents to flow inside the brain by engaging at least two pairs of current-carrying electrodes with the subject's head and applying a voltage to each of the at least two pairs of current-carrying electrodes;   measuring changes in the currents;   generating an average current measurement;   receiving a signal indicative of a pulse rate of the subject;   estimating changes in blood volume of the head, using the measurements of the currents, the average current measurement, and an estimate of total brain blood volume; and   estimating a rate of blood flow in the brain based, at least in part, on the changes in the blood volume of the head and the pulse rate.   
     
     
         60 . The method according to  claim 59 , wherein the voltage applied to each of the at least two pairs of current-carrying electrodes is different for each pair of current-carrying electrodes.