Method and Composition for In Situ Formation and/or Expansion of a Polymer-Based Hemostatic Agent to Control Bleeding

Abstract

A composition for in situ formation and/or expansion of a polymer-based hemostatic agent to control bleeding includes a suitable amount of a polymer or polymer-forming component, hydrogen peroxide or chemical(s) capable of forming hydrogen peroxide, or a combination of both, and a decomposing agent for hydrogen peroxide. The decomposing agent includes an endogenously or exogenously supplied catalyst (other than catalase), or both, and/or the polymer or polymer-forming component.

What is claimed is: 
     
         1 . An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:
 a) providing a polymer-forming component comprising polyvinylsiloxane;   b) providing hydrogen peroxide having a concentration of about 10% to 20% by volume or weight;   c) delivering the polymer-forming component and hydrogen peroxide by injection into the wound or body cavity; and   d) allowing the hydrogen peroxide to come in contact an endogenous or exogenous catalyst comprising platinum, thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.   
     
     
         2 . The method of  claim 1 , wherein:
 the polymer-forming component and hydrogen peroxide are provided in a volume of about 0.1 mL to about 1000 mL.   
     
     
         3 . The method of  claim 1 , wherein:
 the method may be applied consecutively more than once to the wound or body cavity, within a space of time varying between 0.1 second and one year.   
     
     
         4 . The method of  claim 1 , wherein:
 the polymer-forming component additionally comprises at least one member selected from the group consisting of polyurethane, polysiloxane, polyacrylate, siloxane, vinyl polysiloxane, resin, an inorganic polymer, and a combination thereof.   
     
     
         5 . The method of  claim 1 , wherein:
 the catalyst additionally comprises at least one member selected from the group consisting of a metal ion, triethylenediamine (TEDA, also known as 1,4-diazabicyclo[2.2.2]octane or DABCO), dimethylcyclohexylamine (DMCHA), dimethylethanolamine (DMEA), tetramethylbutanediamine (TMBDA), pentamethyldipropylenetriamine, N-(3-dimethylaminopropyl)-N,N-diisopropanolamine, 1,3,5-(tris(3-di methylamino)propyl)-hexahydro-s-triazine, bis-(2-dimethylaminoethyl)ether, N-ethylmorpholine, triethylamine (TEA), 1,8-diazabicyclo[5.4.0]undecene-7 (DBU), pentamethyldiethylenetriamine (PMDETA), benzyldimethylamine (BDMA), tetracaine, and a combination thereof.   
     
     
         6 . The method of  claim 1 , wherein:
 the expanded mass substantially entirely fills up the wound or body cavity.   
     
     
         7 . The method of  claim 1 , wherein:
 the expanded mass configures to assume the shape of the wound or body cavity.   
     
     
         8 . An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:
 a) providing a first component comprising hydrogen peroxide having a concentration of about 10% to 20% by volume or weight;   b) providing a second component comprising an expandable component comprising polyvinylsiloxane;   c) providing a third component comprising a catalyst comprising platinum;   d) delivering the first, second and third components by injection into the wound or body cavity;   e) allowing the catalyst comprising platinum to come in contact with the hydrogen peroxide thereby producing a gas; and   f) allowing the gas to come in contact with the polyvinylsiloxane thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.   
     
     
         9 . The method of  claim 8 , wherein:
 the first, second and third components are provided in a volume of about 0.1 mL to about 1000 mL.   
     
     
         10 . The method of  claim 8 , wherein:
 the method may be applied consecutively more than once to the wound or body cavity, within a space of time varying between 0.1 second and one year.   
     
     
         11 . An injection method for in situ formation of a pressurized obstruction in a wound or bleeding body cavity to control bleeding, comprising the steps of:
 a) providing a polymer-forming component comprising polyvinylsiloxane;   b) providing hydrogen peroxide having a concentration from 16% to 20% by volume or weight;   c) delivering the polymer-forming component and hydrogen peroxide by injection into the wound or body cavity; and   d) allowing the hydrogen peroxide to come in contact an endogenous or exogenous catalyst comprising platinum, thereby producing an expanded mass within 5 seconds to 45 seconds forming a pressurized obstruction to control bleeding in the wound or body cavity.