US2014364327A1PendingUtilityA1

Compositions and Methods for the Systemic Treatment of Arthritis

65
Individually held — no corporate assignee on recordPriority: Feb 26, 2004Filed: Feb 7, 2014Published: Dec 11, 2014
Est. expiryFeb 26, 2024(expired)· nominal 20-yr term from priority
Inventors:Jacques F. BanchereauMaria Virginia Pascual
A61P 43/00A61P 37/00A61P 29/00G01N 33/6869C07K 16/245A61P 19/02C07K 14/545A61K 38/1709A61K 38/2006A61P 19/00A61K 39/395
65
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Claims

Abstract

The present invention includes compositions and methods for treating arthritic joints found in patients with autoinflammation, e.g., systemic onset juvenile idiopathic arthritis, by administering at the site of inflammation a therapeutically effective amount of at least one agent that reduces or blocks the bioavailability of interleukin-1β.

Claims

exact text as granted — not AI-modified
What is claimed is: 
     
         1 .- 24 . (canceled) 
     
     
         25 . A method for evaluating a patient comprising incubating a patient's sera with non-autologous healthy blood mononuclear cells (PBMCs) in vitro; and measuring IL-1β expression in the PBMCs. 
     
     
         26 . The method of  claim 25 , wherein the patient has been treated for SOJIA. 
     
     
         27 . The method of  claim 25 , where the patient has not be treated for SOJIA. 
     
     
         28 . The method of  claim 25 , wherein the sera and PBMCs are incubated for six hours. 
     
     
         29 . The method of  claim 25 , wherein IL-1β expression is measured using a microarray chip. 
     
     
         30 . The method of  claim 25 , further comprising comparing the level of IL-1β expression to the level of expression in a pediatric healthy control. 
     
     
         31 . The method of  claim 25 , wherein the patient has systemic symptoms of SOJIA.

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