US2014364406A1PendingUtilityA1

Method Of Treating Or Preventing Pathologic Effects Of Acute Increases In Hyperglycemia And/Or Acute Increases Of Free Fatty Acid Flux

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Assignee: GURTNER GEOFFREY CPriority: May 24, 2004Filed: Jul 28, 2014Published: Dec 11, 2014
Est. expiryMay 24, 2024(expired)· nominal 20-yr term from priority
Inventors:Geoffrey C. GurtnerMichael Brownlee
A61P 3/10A61P 3/06A61P 3/00A61P 1/16A61K 31/555A61K 31/198A61K 31/385
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Claims

Abstract

One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.

Claims

exact text as granted — not AI-modified
1 . A method of treating a foot ulcer in a diabetic subject, said method comprising:
 administering a superoxide dismutase mimetic to the diabetic subject having a foot ulcer in an amount and manner effective to heal said foot ulcer.   
     
     
         2 . The method of  claim 1 , wherein said superoxide dismutase mimetic is MnTBAP. 
     
     
         3 . The method of  claim 1 , wherein said superoxide dismutase mimetic is ZnTBAP. 
     
     
         4 . The method of  claim 1 , wherein said superoxide dismutase mimetic is SC-55858. 
     
     
         5 . The method of  claim 1 , wherein said superoxide dismutase mimetic is EUK-134.

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